Reactome | rpl-3 [cytosol]

rpl-3 [cytosol]

Stable Identifier

R-CEL-72448

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

RPL3, P50880

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-3 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-3 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-3 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-3 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-3 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P50880

Gene Names

rpl-3

Reference Genes

BioGPS Gene:175501 rpl-3

ENSEMBL:WBGene00004414

KEGG:cel:CELE_F13B10.2 rpl-3

Monarch:175501 rpl-3

NCBI Gene:175501 rpl-3

UCSC:P50880 rpl-3

Wormbase:WBGene00004414

Wormbase:WBGene00004414 rpl-3

Reference Transcript

RefSeq:NM_001026083.7 rpl-3

Other Identifiers

175501

GO:0003723

GO:0003735

GO:0005198

GO:0005737

GO:0005840

GO:0006412

GO:0022625

GO:1990904

Participates

as a component of

Other forms of this molecule

rpl-3 [cytosol]

Inferred From

RPL3,RPL3L [cytosol] (Homo sapiens)

RPL3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001021254.1

ENSEMBL

F13B10.2a.1, F13B10.2a.2, WBGene00004414, F13B10.2a.2, F13B10.2a.1

PRO

P50880

PDB

9BH5, 9CAI

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