Reactome | Rpl3 [cytosol]

Rpl3 [cytosol]

Stable Identifier

R-MMU-72448

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL3, P27659

Locations in the PathwayBrowser

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Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P27659 Rpl3

Gene Names

Rpl3

Chain

chain:1-403

Reference Genes

BioGPS Gene:27367 Rpl3

KEGG:mmu:27367 Rpl3

Monarch:27367 Rpl3

NCBI Gene:27367 Rpl3

UCSC:P27659 Rpl3

Reference Transcript

RefSeq:NM_013762.3 Rpl3

Other Identifiers

100734_at

10430669

10499879

10499881

10515154

10546054

10598721

10600324

1449323_a_at

17319389

17319403

27367

4376574

4435566

4452085

4459603

4574965

4634676

4685134

4784245

4797852

4839131

4842847

4896338

4924644

4934866

4998898

5056151

5080658

5106028

5131779

5142446

5276944

5326780

5339949

5358017

5369469

5418994

5427201

5475980

5498867

5503306

5563218

A_51_P519024

A_66_P108945

A_66_P126077

GE36752

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0032991

GO:0071353

GO:1990904

ILMN_2645672

ILMN_2974021

Y00225_s_at

mMC019526

Participates

as a member of

RPL3,RPL3L [cytosol] (Mus musculus)

Other forms of this molecule

Rpl3 [cytosol]

Inferred From

RPL3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_038790.2

ENSEMBL

ENSMUSP00000080354, ENSMUST00000081650, ENSMUSG00000060036

PRO

P27659

GlyGen

P27659

MGI

1351605

PDB

7CPU, 7LS1, 6SWA, 7LS2, 7CPV

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