Reactome | Rpl3 [cytosol]

Rpl3 [cytosol]

Stable Identifier

R-RNO-72448

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL3, P21531

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL3,RPL3L [cytosol] (Rattus norvegicus)
        
        Rpl3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P21531

Gene Names

Rpl3

Reference Genes

BioGPS Gene:300079 Rpl3

ENSEMBL:ENSRNOG00000016896

ENSEMBL:ENSRNOG00055028945

ENSEMBL:ENSRNOG00060031495

ENSEMBL:ENSRNOG00065033278

KEGG:rno:300079 Rpl3

Monarch:300079 Rpl3

NCBI Gene:300079 Rpl3

UCSC:P21531 Rpl3

Reference Transcript

RefSeq:NM_198753.3 Rpl3

Other Identifiers

10905530

1371300_at

17839259

17839274

300079

5712309

5756369

5772810

5817283

5842807

5912670

5920847

5958307

5974125

6150399

6203088

6285585

6363435

6482570

A_44_P355947

A_64_P062842

GE1234685

GO:0003735

GO:0005198

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0022626

GO:0032991

GO:0071353

ILMN_1351455

PH_rn_0004601

X62166cds_s_at

rc_AA892367_i_at

Participates

as a member of

RPL3,RPL3L [cytosol] (Rattus norvegicus)

Inferred From

RPL3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_942048.1

ENSEMBL

ENSRNOT00000067032, ENSRNOG00000016896, ENSRNOP00000060662

PRO

P21531

RGD

735105

PDB

7QGG

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