Reactome | ADAM33 [plasma membrane]

ADAM33 [plasma membrane]

Stable Identifier

R-HSA-708324

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disintegrin and metalloproteinase domain-containing protein 33, ADA33_HUMAN

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 function (Homo sapiens)
        
        Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)
        
        (ADAM33,ADAM19) (Homo sapiens)
        
        ADAM33 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZ11 ADAM33

Gene Names

ADAM33, C20orf153, UNQ873/PRO1891

Chain

signal peptide:1-29, propeptide:30-203, chain:204-813

Reference Genes

BioGPS Gene:80332 ADAM33

COSMIC (genes):ADAM33 ADAM33

CTD Gene:80332 ADAM33

dbSNP Gene:80332 ADAM33

ENSEMBL:ENSG00000149451 ADAM33

HGNC:15478 ADAM33

KEGG:hsa:80332 ADAM33

Monarch:80332 ADAM33

NCBI Gene:80332 ADAM33

OMIM:607114 ADAM33

UCSC:Q9BZ11 ADAM33

Reference Transcript

Participates

as a candidate of

(ADAM33,ADAM19) (Homo sapiens)

Inferred To

ADAM33 [plasma membrane] (Bos taurus)

ADAM33 [plasma membrane] (Canis familiaris)

ADAM33 [plasma membrane] (Gallus gallus)

ADAM33 [plasma membrane] (Rattus norvegicus)

ADAM33 [plasma membrane] (Sus scrofa)

adam13 [plasma membrane] (Xenopus tropicalis)

Adam33 [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_079496.1, NP_001269376.1, NP_694882.1

Guide to Pharmacology - Targets

1673

ENSEMBL

ENST00000350009, ENSP00000322550, ENST00000356518, ENSP00000348912, ENSG00000149451

OpenTargets

ENSG00000149451

ZINC - Substances

ADA33_HUMAN

ZINC target

Q9BZ11

PRO

Q9BZ11

GlyGen

Q9BZ11

PDB

1R55, 1R54

GeneCards

ADAM33

HPA

ENSG00000149451-ADAM33

Pharos - Targets

Q9BZ11

ZINC - Predictions - Purchasable

ADA33_HUMAN

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) NOTCH3(1572-2321) [Golgi membrane] (R-HSA-156995) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) NICD3 [nucleoplasm] (R-HSA-157928) NICD3 [cytosol] (R-HSA-157647) NEXT3 [plasma membrane] (R-HSA-157203) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517)	0.527	2
UniProt:O75197 LRP5	5	LRP5 [plasma membrane] (R-HSA-201671) p-5S,5T-LRP5 [plasma membrane] (R-HSA-1458893) p-3S,2T-LRP5 [plasma membrane] (R-HSA-1458905) LRP5 [early endosome membrane] (R-HSA-5368479) LRP5 D666_L809del [plasma membrane] (R-HSA-5339694)	0.527	2
UniProt:O75581 LRP6	8	LRP6 [plasma membrane] (R-HSA-206252) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) LRP6N [extracellular region] (R-HSA-5334021) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6 [early endosome membrane] (R-HSA-5368481) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884)	0.527	2
UniProt:Q86XF0 DHFR2	1	DHFR2 [cytosol] (R-HSA-2975816)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:P09601 HMOX1	4	HMOX1 [cytosol] (R-HSA-9609901) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [nucleoplasm] (R-HSA-9708567)	0.527	2

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