Reactome | ADAM33 [plasma membrane]

ADAM33 [plasma membrane]

Stable Identifier

R-HSA-708324

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disintegrin and metalloproteinase domain-containing protein 33, ADA33_HUMAN

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 function (Homo sapiens)
        
        Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform (Homo sapiens)
        
        (ADAM33,ADAM19) (Homo sapiens)
        
        ADAM33 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZ11 ADAM33

Gene Names

ADAM33, C20orf153, UNQ873/PRO1891

Chain

signal peptide:1-29, propeptide:30-203, chain:204-813

Reference Genes

BioGPS Gene:80332 ADAM33

COSMIC (genes):ADAM33 ADAM33

CTD Gene:80332 ADAM33

dbSNP Gene:80332 ADAM33

ENSEMBL:ENSG00000149451 ADAM33

ENSEMBL_homo_sapiens_GENE:ENSG00000149451.19 ADAM33

HGNC:15478 ADAM33

KEGG Gene (Homo sapiens):80332 ADAM33

Monarch:80332 ADAM33

NCBI Gene:80332 ADAM33

OMIM:607114 ADAM33

UCSC:Q9BZ11 ADAM33

Reference Transcript

Other Identifiers

11734962_x_at

11734963_a_at

11734964_x_at

11748650_a_at

16916763

232570_3p_s_at

232570_PM_s_at

232570_s_at

233868_3p_x_at

233868_PM_x_at

233868_x_at

3895553

3895554

3895555

3895557

3895560

3895564

3895565

3895566

3895568

3895570

3895571

3895572

3895575

3895576

3895579

3895580

3895583

3895586

3895588

3895590

3895592

3895593

3895595

3895596

3895598

3895602

3895604

3895606

3895610

80332

8064686

90688_r_at

A_23_P502343

A_33_P3342653

A_33_P3342663

GE56458

GO:0003824

GO:0004222

GO:0005515

GO:0006508

GO:0008233

GO:0008237

GO:0008270

GO:0016020

GO:0016787

GO:0046872

GO:0140096

HMNXSV003002194

HMNXSV003053168

Hs.173716.0.S1_3p_a_at

Hs.173716.0.S1_3p_x_at

Hs.173716.1.S1_3p_a_at

ILMN_1651657

ILMN_1671297

PH_hs_0010412

TC20000574.hg

TC20001390.hg

Participates

as a candidate of

(ADAM33,ADAM19) (Homo sapiens)

Inferred To

ADAM33 [plasma membrane] (Bos taurus)

ADAM33 [plasma membrane] (Canis familiaris)

ADAM33 [plasma membrane] (Drosophila melanogaster)

ADAM33 [plasma membrane] (Gallus gallus)

ADAM33 [plasma membrane] (Mus musculus)

ADAM33 [plasma membrane] (Rattus norvegicus)

ADAM33 [plasma membrane] (Sus scrofa)

ADAM33 [plasma membrane] (Xenopus tropicalis)

Homologues of ADAM33 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001269376.1, NP_079496.1, NP_694882.1

Guide to Pharmacology - Targets

1673

OpenTargets

ENSG00000149451

HPA

ENSG00000149451-ADAM33

ZINC - Substances

ADA33_HUMAN

GeneCards

Q9BZ11

ZINC target

Q9BZ11

Ensembl

ENSP00000322550, ENSP00000348912, ENSG00000149451, ENST00000350009, ENST00000356518

PRO

Q9BZ11

Pharos - Targets

Q9BZ11

ZINC - Predictions - Purchasable

ADA33_HUMAN

PDB

1R54, 1R55

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.527	2
UniProt:O75197 LRP5	5	LRP5 [plasma membrane] (R-HSA-201671) p-5S,5T-LRP5 [plasma membrane] (R-HSA-1458893) p-3S,2T-LRP5 [plasma membrane] (R-HSA-1458905) LRP5 [early endosome membrane] (R-HSA-5368479) LRP5 D666_L809del [plasma membrane] (R-HSA-5339694)	0.527	2
UniProt:Q86XF0 DHFR2	1	DHFR2 [cytosol] (R-HSA-2975816)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911504) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NEXT3 [plasma membrane] (R-HSA-157203) NICD3 [cytosol] (R-HSA-157647) NICD3 [nucleoplasm] (R-HSA-157928) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672)	0.527	2
UniProt:O75581 LRP6	8	p-T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-205884) p-S1490-LRP6 [plasma membrane] (R-HSA-206156) LRP6 [early endosome membrane] (R-HSA-5368481) p-LRP6 [early endosome membrane] (R-HSA-5368496) LRP6N [extracellular region] (R-HSA-5334021) p-2S,S1490,2T-LRP6 [plasma membrane] (R-HSA-1458894) p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane] (R-HSA-1458895) LRP6 [plasma membrane] (R-HSA-206252)	0.527	2

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