Reactome | DHFR2 [cytosol]

DHFR2 [cytosol]

Stable Identifier

R-HSA-2975816

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DHFRL1, Dihydrofolate reductase, mitochondrial ecNumber1.5.1.3/ecNumber, DYRL1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86XF0 DHFR2

Gene Names

DHFR2, DHFRL1, DHFRP4

Chain

chain:1-187

Reference Genes

BioGPS Gene:200895 DHFR2

COSMIC (genes):DHFR2 DHFR2

CTD Gene:200895 DHFR2

dbSNP Gene:200895 DHFR2

ENSEMBL:ENSG00000178700 DHFR2

HGNC:27309 DHFR2

KEGG:hsa:200895 DHFR2

Monarch:200895 DHFR2

NCBI Gene:200895 DHFR2

OMIM:616588 DHFR2

UCSC:Q86XF0 DHFR2

Reference Transcript

Other Identifiers

11729960_x_at

11752574_a_at

16956594

200895

235675_PM_at

235675_at

241727_PM_x_at

241727_x_at

2685355

2685357

2685358

2685359

2685360

2685361

2685362

2685363

2685364

2685365

2685366

2685367

2685368

2864630

46422_at

8089029

A_23_P139312

A_24_P186065

A_33_P3317576

GO:0003723

GO:0003729

GO:0003824

GO:0004146

GO:0005739

GO:0005743

GO:0005759

GO:0005829

GO:0006575

GO:0006730

GO:0006766

GO:0016491

GO:0033560

GO:0043226

GO:0046105

GO:0046452

GO:0046653

GO:0046654

GO:0046655

GO:0050661

GO:0055086

GO:1901135

HMNXSV003032571

Hs.191625.0.A1_3p_at

Hs.43712.0.A1_3p_at

ILMN_1762426

ILMN_2078659

PH_hs_0041081

TC03001592.hg

Inferred To

dhfr [cytosol] (Danio rerio)

DHFR2 [cytosol] (Caenorhabditis elegans)

DHFR2 [cytosol] (Canis familiaris)

DHFR2 [cytosol] (Dictyostelium discoideum)

DHFR2 [cytosol] (Drosophila melanogaster)

DHFR2 [cytosol] (Mus musculus)

DHFR2 [cytosol] (Rattus norvegicus)

DHFR2 [cytosol] (Saccharomyces cerevisiae)

DHFR2 [cytosol] (Schizosaccharomyces pombe)

Homologues of DHFR2 [cytosol] (Canis familiaris)

DHFR [cytosol] (Bos taurus)

DHFR [cytosol] (Canis familiaris)

DHFR [cytosol] (Gallus gallus)

DHFR [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000461173, ENST00000314636, ENSP00000319170, ENST00000619045, ENST00000394221, ENSP00000418415, ENSP00000377768, ENSP00000480823

OpenTargets

ENSG00000178700

HPA

ENSG00000178700-DHFR2

PRO

Q86XF0

Pharos - Targets

Q86XF0

HMDB Protein

HMDBP11725

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UX06 OLFM4	3	OLFM4 [tertiary granule lumen] (R-HSA-6800893) OLFM4 [extracellular region] (R-HSA-6799672) OLFM4 [specific granule lumen] (R-HSA-6799634)	0.527	3
UniProt:P08185 SERPINA6	1	SERPINA6 [extracellular region] (R-HSA-1449658)	0.527	2
UniProt:P10253 GAA	8	GAA [ficolin-1-rich granule membrane] (R-HSA-6800913) GAA [plasma membrane] (R-HSA-6801041) GAA [azurophil granule membrane] (R-HSA-6800877) GAA [tertiary granule membrane] (R-HSA-6801021) GAA (123-?) [lysosomal lumen] (R-HSA-5357560) GAA (204-?) [lysosomal lumen] (R-HSA-5357544) GAA M318T [lysosomal lumen] (R-HSA-5357607) GAA E521K [lysosomal lumen] (R-HSA-5357598)	0.527	2
UniProt:Q8N6Y1 PCD20			0.527	3
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:Q8WWY8 LIPH	1	LIPH [plasma membrane] (R-HSA-6792457)	0.527	2
UniProt:Q76B58 BRNP3			0.527	2
UniProt:Q99445 GML			0.527	2
UniProt:Q9NTU7 CBLN4			0.527	2
UniProt:Q9BZ11 ADAM33	1	ADAM33 [plasma membrane] (R-HSA-708324)	0.527	2
UniProt:Q86T26 TM11B			0.527	2
UniProt:Q9UKJ8 ADAM21	1	ADAM21 [plasma membrane] (R-HSA-1297340)	0.527	3
UniProt:P29016 CD1B	1	CD1B [plasma membrane] (R-HSA-197793)	0.527	2
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	2
UniProt:P05543 THBG			0.527	2

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