Processive synthesis on the lagging strand

Stable Identifier
R-HSA-69183
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Processive synthesis on the lagging strand
Click the image above or here to open this pathway in the Pathway Browser
The key event that allows the processive synthesis on the lagging strand, is polymerase switching from pol alpha to pol delta, as on the leading strand. However, the processive synthesis on the lagging strand proceeds very differently. DNA synthesis is discontinuous, and involves the formation of short fragments called the Okazaki fragments. During the synthesis of Okazaki fragments, the RNA primer is folded into a single-stranded flap, which is removed by endonucleases. This is followed by the ligation of adjacent Okazaki fragments.
Literature References
Participants
Events
Participates
as an event of
Orthologous Events
Processive synthesis on the lagging strand (Bos taurus)
Processive synthesis on the lagging strand (Caenorhabditis elegans)
Processive synthesis on the lagging strand (Canis familiaris)
Processive synthesis on the lagging strand (Dictyostelium discoideum)
Processive synthesis on the lagging strand (Drosophila melanogaster)
Processive synthesis on the lagging strand (Gallus gallus)
Processive synthesis on the lagging strand (Mus musculus)
Processive synthesis on the lagging strand (Plasmodium falciparum)
Processive synthesis on the lagging strand (Rattus norvegicus)
Processive synthesis on the lagging strand (Saccharomyces cerevisiae)
Processive synthesis on the lagging strand (Schizosaccharomyces pombe)
Processive synthesis on the lagging strand (Sus scrofa)
Cite Us!