Lagging Strand Synthesis

Stable Identifier
Homo sapiens
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Due to the antiparallel nature of DNA, DNA polymerization is unidirectional, and one strand is synthesized discontinuously. This strand is called the lagging strand. Although the polymerase switching on the lagging strand is very similar to that on the leading strand, the processive synthesis on the two strands proceeds quite differently. Short DNA fragments, about 100 bases long, called Okazaki fragments are synthesized on the RNA-DNA primers first. Strand-displacement synthesis occurs, whereby the primer-containing 5'-terminus of the adjacent Okazaki fragment is folded into a single-stranded flap structure. This flap structure is removed by endonucleases, and the adjacent Okazaki fragments are joined by DNA ligase.

Literature References
PubMed ID Title Journal Year
9081985 Enzymes and reactions at the eukaryotic DNA replication fork.

Bambara, RA, Murante, RS, Henricksen, LA

J Biol Chem 1997
Orthologous Events
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