Joining of adjacent Okazaki fragments

Stable Identifier
R-HSA-69173
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Removal of the flap by FEN-1 leads to the generation of a nick between the 3'-end of the upstream Okazaki fragment and the 5'-end of the downstream Okazaki fragment. DNA ligase I then seals the nicks between adjacent processed Okazaki fragments to generate intact double-stranded DNA.

Literature References
PubMed ID Title Journal Year
9081985 Enzymes and reactions at the eukaryotic DNA replication fork.

Bambara, RA, Murante, RS, Henricksen, LA

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events