Formation of Okazaki fragments

Stable Identifier
R-HSA-69116
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of Okazaki fragments
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After RFC initiates the assembly of the primer recognition complex, the complex of pol delta and PCNA is responsible for incorporating the additional nucleotides prior to the position of the next downstream initiator RNA primer. On the lagging strand, short discontinuous segments of DNA, called Okazaki fragments, are synthesized on RNA primers. The average length of the Okazaki fragments is 100 nucleotides. Polymerase switching is a key event that allows the processive synthesis of DNA by the pol delta and PCNA complex (Lee and Hurwitz 1990, Tsurimoto and Stillman 1991, Nethanel et al. 1992, Brown and Campbell 1993, Waga et al.1994, Bambara et al. 1997).
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Catalyst Activity

DNA-directed DNA polymerase activity of DNA Polymerase delta tetramer [nucleoplasm]

Physical Entity
DNA Polymerase delta tetramer [nucleoplasm] (Homo sapiens)
Activity
DNA-directed DNA polymerase activity (GO:0003887)
Orthologous Events
Formation of Okazaki fragments (Bos taurus)
Formation of Okazaki fragments (Caenorhabditis elegans)
Formation of Okazaki fragments (Canis familiaris)
Formation of Okazaki fragments (Danio rerio)
Formation of Okazaki fragments (Dictyostelium discoideum)
Formation of Okazaki fragments (Gallus gallus)
Formation of Okazaki fragments (Mus musculus)
Formation of Okazaki fragments (Rattus norvegicus)
Formation of Okazaki fragments (Schizosaccharomyces pombe)
Formation of Okazaki fragments (Sus scrofa)
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