Formation of the Flap Intermediate

Stable Identifier
R-HSA-69127
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Formation of the Flap Intermediate
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When the polymerase delta:PCNA complex reaches a downstream Okazaki fragment, strand displacement synthesis occurs. The primer containing 5'-terminus of the downstream Okazaki fragment is folded into a single-stranded flap.

Literature References
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Orthologous Events
Formation of the Flap Intermediate (Caenorhabditis elegans)
Formation of the Flap Intermediate (Canis familiaris)
Formation of the Flap Intermediate (Danio rerio)
Formation of the Flap Intermediate (Dictyostelium discoideum)
Formation of the Flap Intermediate (Drosophila melanogaster)
Formation of the Flap Intermediate (Mus musculus)
Formation of the Flap Intermediate (Plasmodium falciparum)
Formation of the Flap Intermediate (Rattus norvegicus)
Formation of the Flap Intermediate (Saccharomyces cerevisiae)
Formation of the Flap Intermediate (Schizosaccharomyces pombe)
Formation of the Flap Intermediate (Sus scrofa)
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