IER3 recruits MAPKs to PP2A-B56-beta,gamma

Stable Identifier
R-HSA-6811472
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
IEX1 recruits ERKs to PP2A
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IER3 (IEX-1) recruits both an activated MAPK (MAPK1 (ERK2) or MAPK3 (ERK1)) and the protein phosphatase 2A (PP2A) complex containing regulatory subunits B56-beta (PPP2R5B) or B56-gamma (PPP2R5C), through an interaction with the B56 subunit, forming a tripartite complex (Letourneux et al. 2006, Rocher et al. 2007).

Literature References
PubMed ID Title Journal Year
17200115 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

Rocher, G, Letourneux, C, Lenormand, P, Porteu, F

J. Biol. Chem. 2007
16456541 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

Letourneux, C, Rocher, G, Porteu, F

EMBO J 2006
Participants
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Orthologous Events
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