Reactome | CARD8 [cytosol]

CARD8 [cytosol]

Stable Identifier

R-HSA-6805447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Caspase recruitment domain-containing protein 8, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9, CARD-inhibitor of NF-kappa-B-activating ligand, Apoptotic protein NDPP1, CARDINAL

Locations in the PathwayBrowser for interactor UniProt:Q5VUJ6 LRCH2

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External Reference Information

External Reference

UniProt:Q9Y2G2 CARD8

Gene Names

CARD8, DACAR, KIAA0955, NDPP1

Chain

chain:1-537, chain:1-296, chain:297-537

Reference Genes

BioGPS Gene:22900 CARD8

COSMIC - genes:CARD8 CARD8

CTD Gene:22900 CARD8

dbSNP Gene:22900 CARD8

ENSEMBL:ENSG00000105483 CARD8

HGNC:17057 CARD8

KEGG:hsa:22900 CARD8

Monarch:22900 CARD8

NCBI Gene:22900 CARD8

OMIM:609051 CARD8

UCSC:Q9Y2G2 CARD8

Reference Transcript

Participates

as a component of

CASP9:CARD [cytosol] (Homo sapiens)

as an input of

CARD8 binds CASP9(1-416) (Homo sapiens)

This entity regulates

Negatively

CYCS:APAF1 binds procaspase-9 (Homo sapiens)

Inferred To

Homologues of CARD8 [cytosol] (Danio rerio)

CARD8 [cytosol] (Canis familiaris)

CARD8 [cytosol] (Gallus gallus)

pycard [cytosol] (Danio rerio)

si:dkey-10c21.1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_055774.2, NP_001338712.1, NP_001338711.1, NP_001171829.1, NP_001171832.1, NP_001171831.1, NP_001352879.1, NP_001171830.1, NP_001171833.1

ENSEMBL

ENSP00000375767, ENSP00000428736, ENST00000521613, ENST00000391898, ENSP00000430747, ENSP00000391248, ENST00000447740, ENSP00000430108, ENST00000519940, ENST00000520015, ENSP00000427727, ENSP00000427858, ENST00000519332, ENST00000651546, ENST00000520007, ENSG00000105483, ENST00000520753, ENST00000520153, ENSP00000429839, ENSP00000428883, ENSP00000427922, ENST00000522431, ENSP00000499211

OpenTargets

ENSG00000105483

HPA

ENSG00000105483-CARD8

GeneCards

CARD8

PRO

Q9Y2G2

Pharos - Targets

Q9Y2G2

PDB

4IKM, 7JN7, 6XKJ, 6K9F, 7JKQ

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.527	2
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.527	2
UniProt:Q9Y467 SALL2			0.527	2
UniProt:Q9NWK9 BCD1			0.527	2
UniProt:Q15906 VPS72	1	VPS72 [nucleoplasm] (R-HSA-3321992)	0.527	2
UniProt:Q9ULM3 YEATS2	1	YEATS2 [nucleoplasm] (R-HSA-3321976)	0.527	2
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.527	2
UniProt:Q5VUJ6 LRCH2			0.527	2
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.527	2
UniProt:Q8TEP8 CEP192	1	CEP192 [cytosol] (R-HSA-380319)	0.527	2
UniProt:Q5T3J3 LRIF1			0.527	2
UniProt:Q9BZG8 DPH1	1	DPH1 [cytosol] (R-HSA-5358384)	0.527	2
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.527	2
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	2
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.508	2
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.508	2

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