Reactome | MGA [nucleoplasm]

MGA [nucleoplasm]

Stable Identifier

R-HSA-8953093

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MAX gene-associated protein, MAX dimerization protein 5, MAD5, KIAA0518, MGAP_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
      - E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
      - E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
      - EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IWI9 MGA

Gene Names

MGA, KIAA0518, MAD5

Chain

chain:1-3065

Reference Genes

BioGPS Gene:23269 MGA

COSMIC (genes):MGA MGA

CTD Gene:23269 MGA

dbSNP Gene:23269 MGA

ENSEMBL:ENSG00000174197 MGA

HGNC:14010 MGA

KEGG:hsa:23269 MGA

Monarch:23269 MGA

NCBI Gene:23269 MGA

OMIM:616061 MGA

UCSC:Q8IWI9 MGA

Reference Transcript

Other Identifiers

11743706_a_at

11751875_a_at

11758283_s_at

16799882

212945_PM_s_at

212945_s_at

23269

235409_PM_at

235409_at

34706_at

3590554

3590555

3590559

3590560

3590562

3590563

3590564

3590566

3590567

3590568

3590569

3590570

3590571

3590572

3590573

3590580

3590581

3590582

3590583

3590584

3590586

3590587

3590588

3590589

3590591

3590593

3590594

3590595

3590596

3590597

3590599

3590601

3590602

3590603

3590604

3590605

3590606

3590607

3590608

3590609

3590610

3590611

3590612

3590613

3590614

3590615

3590616

3590617

3590627

3590628

3590629

3590630

3590631

3590632

3590633

3590634

3590635

72701_at

72702_i_at

72704_r_at

7982957

86193_at

A_23_P37654

A_23_P49052

A_24_P40968

A_32_P84342

A_33_P3330323

A_33_P3398437

GE53251

GE84837

GE852139

GO:0000785

GO:0000978

GO:0000981

GO:0001708

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0043226

GO:0045893

GO:0046983

GO:0071339

GO:0140110

HMNXSV003008384

HMNXSV003044402

Hs.194324.0.S1_3p_at

Hs.23763.0.A1_3p_at

ILMN_2372379

ILMN_2372384

PH_hs_0025455

TC15000311.hg

TC15002167.hg

Participates

as a component of

MGA:MAX [nucleoplasm] (Homo sapiens)

Inferred To

MGA [nucleoplasm] (Bos taurus)

MGA [nucleoplasm] (Canis familiaris)

MGA [nucleoplasm] (Gallus gallus)

MGA [nucleoplasm] (Sus scrofa)

org-1 [nucleoplasm] (Drosophila melanogaster)

mga [nucleoplasm] (Xenopus tropicalis)

tbx-35 [nucleoplasm] (Caenorhabditis elegans)

Mga [nucleoplasm] (Mus musculus)

Mga [nucleoplasm] (Rattus norvegicus)

tbx-7 [nucleoplasm] (Caenorhabditis elegans)

Homologues of MGA [nucleoplasm] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000219905, ENSP00000219905, ENST00000566586, ENSP00000456141

OpenTargets

ENSG00000174197

HPA

ENSG00000174197-MGA

PRO

Q8IWI9

Pharos - Targets

Q8IWI9

GlyGen

Q8IWI9

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.788	5
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.738	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	5
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	4
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.643	5
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.643	4
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.527	3
UniProt:Q9Y2G2 CARD8	1	CARD8 [cytosol] (R-HSA-6805447)	0.527	2
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.483	2