Several binding partners of CARD8 have been reported. CARD8 can interact physically via CARD domain with caspase-1 and negatively regulates caspase-1-dependent IL-1beta generation in the THP-1 monocytic cell line (Razmara M et al. 2002). The FIIND domain of CARD8 may inhibit NFkappaB activation, possibly through interaction with IKKgamma (Bouchier-Hayes L et al. 2001). FIIND may also bind the nucleotide-binding domain (NBD) domain of NOD2 and NLRP3 to regulate the immune response to bacterial infections (Kampen O et al. 2010).
High levels of CARD8 expression have been observed in several tumor cell lines and malignant specimens from human patients underlying its importance in regulating inflammatory and apoptotic pathways (Bouchier-Hayes L et al. 2001; Pathan N et al. 2001; Razmara M et al. 2002; Zhang H & Fu W 2002; Yamamoto M et al. 2005).
Krajewska, M, Kim, H, Marusawa, H, Pathan, N, Godzik, A, Pio, F, Kitada, S, Okada, K, Reed, JC, Matsuzawa, S, Welsh, K, Krajewski, S, Torii, S
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