HGFAC cleaves pro-HGF to form HGF dimer

Stable Identifier
R-HSA-6800299
Type
Reaction
Species
Homo sapiens
Compartment
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HGF is a pleiotropic factor and activates hepatocyte growth factor receptor (MET), a proto-oncogenic receptor tyrosine kinase. HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage at Arg494–Val495 to form the biologically active alpha-beta heterodimer. Hepatocyte growth factor activator (HGFAC, commonly known as HGFA) is a serine protease that converts HGF into its active form (Shia et al. 2005). The Kunitz-type protease inhibitor 1 (SPINT1, aka HAI1) is an inhibitor of HGFAC activity (Shia et al. 2005).

Literature References
PubMed ID Title Journal Year
15713485 Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Kirchhofer, D, Shia, S, Corpuz, RT, Stamos, J, Santell, L, Fan, B, Eigenbrot, C, Wu, J, Lazarus, RA

J. Mol. Biol. 2005
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Catalyst Activity

serine-type endopeptidase activity of HGFAC dimer [extracellular region]

This event is regulated
Orthologous Events
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