Reactome | HGFAC cleaves pro-HGF to form HGF dimer

HGFAC cleaves pro-HGF to form HGF dimer

Stable Identifier

R-HSA-6800299

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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HGF is a pleiotropic factor and activates hepatocyte growth factor receptor (MET), a proto-oncogenic receptor tyrosine kinase. HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage at Arg494–Val495 to form the biologically active alpha-beta heterodimer. Hepatocyte growth factor activator (HGFAC, commonly known as HGFA) is a serine protease that converts HGF into its active form (Shia et al. 2005). The Kunitz-type protease inhibitor 1 (SPINT1, aka HAI1) is an inhibitor of HGFAC activity (Shia et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15713485	Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B Shia, S, Stamos, J, Kirchhofer, D, Fan, B, Wu, J, Corpuz, RT, Santell, L, Lazarus, RA, Eigenbrot, C	J. Mol. Biol.	2005