HGF is a pleiotropic factor and activates hepatocyte growth factor receptor (MET), a proto-oncogenic receptor tyrosine kinase. HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage at Arg494–Val495 to form the biologically active alpha-beta heterodimer. Hepatocyte growth factor activator (HGFAC, commonly known as HGFA) is a serine protease that converts HGF into its active form (Shia et al. 2005). The Kunitz-type protease inhibitor 1 (SPINT1, aka HAI1) is an inhibitor of HGFAC activity (Shia et al. 2005).
Kirchhofer, D, Shia, S, Corpuz, RT, Stamos, J, Santell, L, Fan, B, Eigenbrot, C, Wu, J, Lazarus, RA
serine-type endopeptidase activity of HGFAC dimer [extracellular region]
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