Reactome | p-Y446-IL10RA [plasma membrane]

p-Y446-IL10RA [plasma membrane]

Stable Identifier

R-HSA-6784810

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-10 receptor alpha chain, I10R1_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-10 signaling (Homo sapiens)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Homo sapiens)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Homo sapiens)
        
        p-Y-IL10RA [plasma membrane] (Homo sapiens)
        
        p-Y446-IL10RA [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13651 IL10RA

Gene Names

IL10RA, IL10R

Chain

signal peptide:1-21, chain:22-578

Reference Genes

BioGPS Gene:3587 IL10RA

COSMIC (genes):IL10RA IL10RA

CTD Gene:3587 IL10RA

dbSNP Gene:3587 IL10RA

ENSEMBL:ENSG00000110324 IL10RA

ENSEMBL:ENSG00000110324.12 IL10RA

HGNC:5964 IL10RA

KEGG Gene (Homo sapiens):3587 IL10RA

Monarch:3587 IL10RA

NCBI Gene:3587 IL10RA

OMIM:146933 IL10RA

UCSC:Q13651 IL10RA

Reference Transcript

RefSeq:NM_001558.3 IL10RA

Other Identifiers

1061_at

1062_g_at

11729747_a_at

11729748_a_at

16731754

204912_PM_at

204912_at

3351167

3351168

3351171

3351172

3351173

3351175

3351177

3351181

3351184

3351185

3351186

3351187

3351189

35659_at

3587

7896694

7896711

7944152

A_24_P107303

A_24_P52733

GE58838

GE903332

GO:0004920

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006914

GO:0006954

GO:0010507

GO:0016020

GO:0016192

GO:0016324

GO:0019221

GO:0019969

GO:0022600

GO:0023052

GO:0032496

GO:0034330

GO:0038023

GO:0046427

GO:0050728

GO:0050807

GO:0060089

GO:0060729

GO:0070086

HMNXSV003047025

ILMN_1652825

PH_hs_0000040

PH_hs_0034181

TC11001058.hg

TC11002896.hg

U00672_at

g4504632_3p_at

Participates

as a member of

p-Y-IL10RA [plasma membrane] (Homo sapiens)

Other forms of this molecule

IL10RA [plasma membrane]

p-Y496-IL10RA [plasma membrane]

Inferred To

phospho-il22ra1 [plasma membrane] (Xenopus tropicalis)

phospho-Il10ra [plasma membrane] (Mus musculus)

phospho-Il10ra [plasma membrane] (Rattus norvegicus)

phospho-p-Y446-IL10RA [plasma membrane] (Danio rerio)

phospho-p-Y446-IL10RA [plasma membrane] (Gallus gallus)

phospho-IL10RA [plasma membrane] (Bos taurus)

phospho-IL10RA [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 446

Coordinate

446

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001549.2

Guide to Pharmacology - Targets

1727

OpenTargets

ENSG00000110324

HPA

ENSG00000110324-IL10RA

GeneCards

Q13651

Ensembl

ENSP00000227752, ENST00000227752, ENSG00000110324

PRO

Q13651

Pharos - Targets

Q13651

Orphanet

19497

PDB

1J7V, 6X93, 1LQS, 1Y6M, 5IXI, 1Y6N, 1Y6K

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22301 IL10	1	IL10 [extracellular region] (R-HSA-447125)	0.862	9
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.675	6
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3

Cite Us!