Reactome | 7a [virion membrane]

7a [virion membrane]

Stable Identifier

R-COV-9694648

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

virion membrane

Synonyms

P0DTC7

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Early SARS-CoV-2 Infection Events (Homo sapiens)
        
        Attachment and Entry (Homo sapiens)
        
        Cleavage of S protein into S1:S2 (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike:heparin [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
        
        S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike binds Spike inhibitors (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike:Spike inhibitors [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Spike:Spike inhibitors [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Induction of Cell-Cell Fusion (Homo sapiens)
        
        FURIN Mediated SARS-CoV-2 Spike Protein Cleavage (Homo sapiens)
        
        Spike:heparin [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Virion Assembly and Release (Homo sapiens)
        
        SARS virus buds into ERGIC lumen (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [exocytic vesicle] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        Viral release (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [exocytic vesicle] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 S binds SFTPD 12mer (Homo sapiens)
        
        SFTPD:S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        TLR2:TLR1 binds SARS-CoV-2 E pentamer (Homo sapiens)
        
        TLR2:TLR1:E:S3:M:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [plasma membrane] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region] (Severe acute respiratory syndrome coronavirus 2)
        
        7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)
        
        7a [virion membrane] (Severe acute respiratory syndrome coronavirus 2)

General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

External Reference Information

External Reference

UniProt:P0DTC7 7a

Gene Names

Chain

signal peptide:1-15, chain:16-121

Reference Genes

BioGPS Gene:43740573 7a

Monarch:43740573 7a

NCBI Gene:43740573 7a

UCSC:P0DTC7 7a

Reference Transcript

RefSeq:NC_045512.2 7a

Participates

as a component of

7a:O-glycosyl 3a tetramer [virion membrane] (Severe acute respiratory syndrome coronavirus 2)

Other forms of this molecule

7a [endolysosome membrane]

7a [endoplasmic reticulum membrane]

7a [endoplasmic reticulum-Golgi intermediate compartment membrane]

7a [endocytic vesicle membrane]

Inferred From

7a [virion membrane] (Human SARS coronavirus)

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

RefSeq

YP_009724395.1

PDB

6W37, 7CI3

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NU22 MDN1			0.643	3
UniProt:P0DTD1-PRO_0000449625 REP			0.621	3
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.547	2
UniProt:Q9HD20 ATP13A1	1	ATP13A1 [endoplasmic reticulum membrane] (R-HSA-939749)	0.547	2
UniProt:Q8N1F7 NUP93	2	NUP93 [cytosol] (R-HSA-9634167) NUP93 [nuclear envelope] (R-HSA-157749)	0.547	2
UniProt:Q9HAV4 XPO5	2	XPO5 [cytosol] (R-HSA-847719) XPO5 [nucleoplasm] (R-HSA-847721)	0.547	2
UniProt:Q9UI26 IPO11			0.547	2
UniProt:Q6YHU6 THADA	1	THADA [cytoplasm] (R-HSA-8870282)	0.547	2
UniProt:Q7Z4Q2 HEAT3			0.527	2
UniProt:P05023 ATP1A1	1	ATP1A1 [plasma membrane] (R-HSA-936850)	0.527	2
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:P0DTC7 7a	5	7a [endolysosome membrane] (R-COV-9755945) 7a [endoplasmic reticulum membrane] (R-COV-9727308) 7a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694750) 7a [endocytic vesicle membrane] (R-COV-9694645) 7a [virion membrane] (R-COV-9694648)	0.519	2
UniProt:P0DTD8 NS7B			0.519	5

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