USP19 promotes the stability of BIRC2 (c-IAP1) and BIRC3 (c-IAP2) by preventing them from self-ubiquitinating (Mei et al. 2011). Similarly, USP19 promotes the stability of the hypoxia-inducible factor 1-alpha (HIF-1a), with a mechanism that is independent of its catalytic activity (Altun et al. 2012).
Hahn, AA, Mei, Y, Yang, X, Hu, S
Paschke, J, Altun, M, Hassink, G, Liu, H, Pereira, T, Velasco, K, Zhao, B, Lindsten, K
© 2022 Reactome
