USP19 promotes the stability of BIRC2 (c-IAP1) and BIRC3 (c-IAP2) by preventing them from self-ubiquitinating (Mei et al. 2011). Similarly, USP19 promotes the stability of the hypoxia-inducible factor 1-alpha (HIF-1a), with a mechanism that is independent of its catalytic activity (Altun et al. 2012).
Altun, M, Zhao, B, Velasco, K, Liu, H, Hassink, G, Paschke, J, Pereira, T, Lindsten, K
Mei, Y, Hahn, AA, Hu, S, Yang, X
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