USP19 binds HIF1A,BIRC2,BIRC3

Stable Identifier
R-HSA-6781797
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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USP19 binds HIF1A,BIRC2,BIRC3
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USP19 promotes the stability of BIRC2 (c-IAP1) and BIRC3 (c-IAP2) by preventing them from self-ubiquitinating (Mei et al. 2011). Similarly, USP19 promotes the stability of the hypoxia-inducible factor 1-alpha (HIF-1a), with a mechanism that is independent of its catalytic activity (Altun et al. 2012).

Literature References
PubMed ID Title Journal Year
22128162 Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia

Altun, M, Zhao, B, Velasco, K, Liu, H, Hassink, G, Paschke, J, Pereira, T, Lindsten, K

J. Biol. Chem. 2012
21849505 The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2

Mei, Y, Hahn, AA, Hu, S, Yang, X

J. Biol. Chem. 2011
Participants
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Output
Participant Of
hasEvent
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Authored
Jupe, S  (2015-04-16)
Reviewed
Meldal, BH  (2016-05-16)
Created
Jupe, S  (2015-06-02)