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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
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Cytomics
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FAQ
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VWF(23-763) [extracellular region]
Stable Identifier
R-HSA-67271
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
VWF, Von Willebrand factor precursor, vWF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
GP1b signaling involves c-Src (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V binds filamin (Homo sapiens)
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
vWF binds to collagen (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Thrombin binding to GP1b:IX:V (Homo sapiens)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04275 VWF
Gene Names
VWF, F8VWF
Chain
signal peptide:1-22, chain:23-763, chain:764-2813
Reference Genes
BioGPS Gene:7450 P042752
COSMIC (genes):VWF VWF
CTD Gene:7450 VWF
dbSNP Gene:7450 VWF
ENSEMBL:ENSG00000110799 VWF
HGNC:12726 P042752
KEGG:hsa:7450 P042752
Monarch:7450 P042752
NCBI Gene:7450 P042752
OMIM:613160 P042752
UCSC:P04275 P042752
Reference Transcript
RefSeq:NM_000552.4 P042752
RefSeq:NM_000552.5 P042752
RefSeq:XM_047429501.1 P042752
Participates
as an input of
vWF binds to collagen (Homo sapiens)
as a component of
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
Other forms of this molecule
VWF(23-763) [platelet alpha granule lumen]
VWF(764-2813) [extracellular region]
VWF L1733P (764-2813) [extracellular region]
VWF S1731L (764-2813) [extracellular region]
VWF K1794E (764-2813) [extracellular region]
VWF S1731T (764-2813) [extracellular region]
VWF S1783A (764-2813) [extracellular region]
VWF H1786D (764-2813) [extracellular region]
VWF W1745C (764-2813) [extracellular region]
VWF(764-1605) [extracellular region]
VWF (1606-2813) [extracellular region]
VWF G1579R (764-2813) [extracellular region]
VWF Y1584C (764-2813) [extracellular region]
VWF G1631D (764-2813) [extracellular region]
VWF C1099P (764-2813) [extracellular region]
VWF I1568N (764-2813) [extracellular region]
VWF Y1584C (764-1605) [extracellular region]
VWF G1631D (1606-2813) [extracellular region]
VWF I1568N (764-1605) [extracellular region]
VWF C1099P (764-1605) [extracellular region]
VWF G1579R (764-1605) [extracellular region]
VWF S1358N (764-2813) [extracellular region]
VWF S1387I (764-2813) [extracellular region]
VWF S1394F (764-2813) [extracellular region]
VWF Q1402P (764-2813) [extracellular region]
Inferred To
Ghost homologue of VWF(23-763) [extracellular region]
(Rattus norvegicus)
VWF(23-763) [extracellular region]
(Gallus gallus)
VWF [extracellular region]
(Bos taurus)
VWF [extracellular region]
(Canis familiaris)
VWF [extracellular region]
(Sus scrofa)
Homologues of VWF(23-763) [extracellular region]
(Canis familiaris)
vwf [extracellular region]
(Danio rerio)
vwf [extracellular region]
(Xenopus tropicalis)
Vwf [extracellular region]
(Mus musculus)
Hml [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000543.3
,
NP_000543.2
,
XP_047285457.1
OpenTargets
ENSG00000110799
ENSEMBL
ENSG00000110799
,
ENSP00000261405
,
ENST00000261405
GeneCards
VWF
HPA
ENSG00000110799-VWF
ZINC - Substances
VWF_HUMAN
ZINC target
P04275
PRO
P04275
Pharos - Targets
P04275
GlyGen
P04275
Orphanet
VWF
PDB
1SQ0
,
6N29
,
3GXB
,
2ADF
,
1FNS
,
7P4N
,
1AUQ
,
3PPY
,
7ZWH
,
3PPX
,
1IJK
,
3PPW
,
4C29
,
8D3C
,
7EOW
,
8D3D
,
5BV8
,
7PNF
,
1AO3
,
1UEX
,
1IJB
,
1U0N
,
7F49
,
3ZQK
,
4NT5
,
7PMV
,
3PPV
,
3HXQ
,
7KWO
,
1ATZ
,
3HXO
,
4DMU
,
6FWN
,
1M10
,
4C2A
,
1FE8
,
1OAK
,
2MHQ
,
2MHP
,
4C2B
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04275 VWF
20
VWF(23-763) [extracellular region]
(R-HSA-67271)
VWF(23-763) [platelet alpha granule lumen]
(R-HSA-114662)
VWF(764-2813) [extracellular region]
(R-HSA-158327)
VWF L1733P (764-2813) [extracellular region]
(R-HSA-9824345)
VWF S1731L (764-2813) [extracellular region]
(R-HSA-9823681)
VWF K1794E (764-2813) [extracellular region]
(R-HSA-9823657)
VWF S1731T (764-2813) [extracellular region]
(R-HSA-9823615)
VWF S1783A (764-2813) [extracellular region]
(R-HSA-9823588)
VWF H1786D (764-2813) [extracellular region]
(R-HSA-9823634)
VWF W1745C (764-2813) [extracellular region]
(R-HSA-9823611)
VWF(764-1605) [extracellular region]
(R-HSA-9822545)
VWF (1606-2813) [extracellular region]
(R-HSA-9822534)
VWF G1579R (764-2813) [extracellular region]
(R-HSA-9844214)
VWF Y1584C (764-2813) [extracellular region]
(R-HSA-9844202)
VWF G1631D (764-2813) [extracellular region]
(R-HSA-9844230)
VWF C1099P (764-2813) [extracellular region]
(R-HSA-9844221)
VWF I1568N (764-2813) [extracellular region]
(R-HSA-9844203)
VWF Y1584C (764-1605) [extracellular region]
(R-HSA-9852765)
VWF G1631D (1606-2813) [extracellular region]
(R-HSA-9852788)
VWF I1568N (764-1605) [extracellular region]
(R-HSA-9852790)
0.868
21
UniProt:Q76LX8 ADAMTS13
7
glc-fuc-ADAMTS13 [extracellular region]
(R-HSA-9822541)
ADAMTS13 A250V [extracellular region]
(R-HSA-9824393)
ADAMTS13 Q449* [extracellular region]
(R-HSA-9824391)
ADAMTS13 P475S [extracellular region]
(R-HSA-9824387)
O-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173286)
glc-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5172961)
ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173292)
0.789
19
UniProt:P00451 F8
20
F8(392-759) D579A [plasma membrane]
(R-HSA-9668364)
F8(392-759) V578A [plasma membrane]
(R-HSA-9668367)
F8(392-759) R546W [plasma membrane]
(R-HSA-9668360)
F8(392-759) S577F [plasma membrane]
(R-HSA-9668362)
F8(392-759) I585T [plasma membrane]
(R-HSA-9668357)
F8 N637S [endoplasmic reticulum lumen]
(R-HSA-9661996)
F8 G2013R [endoplasmic reticulum lumen]
(R-HSA-9666350)
F8 W604R [endoplasmic reticulum lumen]
(R-HSA-9661993)
F8 R1126W [endoplasmic reticulum lumen]
(R-HSA-9662699)
F8 R2326L [endoplasmic reticulum lumen]
(R-HSA-9661995)
F8 P947R [endoplasmic reticulum lumen]
(R-HSA-9662692)
F8 H1066Y [endoplasmic reticulum lumen]
(R-HSA-9662693)
F8 S603G [endoplasmic reticulum lumen]
(R-HSA-9661989)
F8 E1057K [endoplasmic reticulum lumen]
(R-HSA-9662694)
F8 E600D [endoplasmic reticulum lumen]
(R-HSA-9661991)
F8 W604C [endoplasmic reticulum lumen]
(R-HSA-9661984)
F8 D845E [endoplasmic reticulum lumen]
(R-HSA-9662689)
F8 G720S [endoplasmic reticulum lumen]
(R-HSA-9661985)
F8 E600Q [endoplasmic reticulum lumen]
(R-HSA-9662015)
F8 R2326Q [endoplasmic reticulum lumen]
(R-HSA-9661945)
0.623
2
UniProt:P07359 GP1BA
6
GP1BA [plasma membrane]
(R-HSA-55861)
GP1BA D251Y [plasma membrane]
(R-HSA-9844197)
GP1BA W246L [plasma membrane]
(R-HSA-9844258)
GP1BA M255V [plasma membrane]
(R-HSA-9844240)
GP1BA G249V [plasma membrane]
(R-HSA-9844257)
GP1BA G249S [plasma membrane]
(R-HSA-9844280)
0.623
2
UniProt:P00451-PRO_0000002967 F8
0.544
2
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.454
2
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![VWF(23-763) [extracellular region] icon](/icon/R-ICO-013525.svg){kind=icon}
