Reactome | VWF(23-763) [extracellular region]

VWF(23-763) [extracellular region]

Stable Identifier

R-HSA-67271

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

VWF, Von Willebrand factor precursor, vWF

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Signaling by BRAF and RAF fusions (Homo sapiens)
      - Dissociation of BRAF/RAF fusion complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - Signaling downstream of RAS mutants (Homo sapiens)
        
        Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Signaling by high-kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Dissociation of high activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Dissociation of moderate activity BRAF complexes (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet Adhesion to exposed collagen (Homo sapiens)
  - GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
    - Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
      - VWF(23-763) [extracellular region] (Homo sapiens)
    - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
      - Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
  - vWF binds to collagen (Homo sapiens)
    - Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
      - VWF(23-763) [extracellular region] (Homo sapiens)
    - VWF(23-763) [extracellular region] (Homo sapiens)
- Platelet activation, signaling and aggregation (Homo sapiens)
  - GP1b-IX-V activation signalling (Homo sapiens)
    - GP1b signaling involves c-Src (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - GP1b-IX-V binds filamin (Homo sapiens)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Homo sapiens)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin alphaIIb beta3 signaling (Homo sapiens)
      - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Autophosphorylation of SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
        
        Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Recruitment of GRB2 to p-PTK2 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Phosphorylation of pPTK2 by SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Release of CSK from SRC (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - SYK activation by SRC (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Translocation of PTK2 to Focal complexes (Homo sapiens)
        
        Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Thrombin binding to GP1b:IX:V (Homo sapiens)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
        
        Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Integrin signaling (Homo sapiens)
  - Integrin alphaIIb beta3 signaling (Homo sapiens)
    - Autophosphorylation of PTK2 at Y397 (Homo sapiens)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Autophosphorylation of SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
      - Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
      - Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Recruitment of GRB2 to p-PTK2 (Homo sapiens)
        
        GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
      - Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Phosphorylation of pPTK2 by SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Release of CSK from SRC (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - SYK activation by SRC (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - SYK binds to integrin alphaIIb beta3 (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - Translocation of PTK2 to Focal complexes (Homo sapiens)
      - Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
    - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
      - Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
      - Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
        
        BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
        
        Focal complex [plasma membrane] (Homo sapiens)
        
        Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
        
        VWF(23-763) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04275 VWF

Gene Names

VWF, F8VWF

Chain

signal peptide:1-22, chain:23-763, chain:764-2813

Reference Genes

BioGPS Gene:7450 VWF

COSMIC (genes):VWF VWF

CTD Gene:7450 VWF

dbSNP Gene:7450 VWF

ENSEMBL:ENSG00000110799 VWF

HGNC:12726 VWF

KEGG Gene (Homo sapiens):7450 VWF

Monarch:7450 VWF

NCBI Gene:7450 VWF

OMIM:613160 VWF

UCSC:P04275 VWF

Reference Transcript

RefSeq:NM_000552.4 VWF

Other Identifiers

11724540_a_at

11724541_s_at

11747176_a_at

11751779_a_at

11752216_a_at

16760257

1694

17123028

17123030

17123032

1815

1AO3

1ATZ

1AUQ

1FE8

1FNS

1IJB

1IJK

1M10

1OAK

1SQ0

1U0N

1UEX

202112_at

2082

233980_s_at

2ADF

2MHP

2MHQ

3441686

3441687

3441688

3441689

3441691

3441693

3441695

3441696

3441699

3441700

3441701

3441702

3441705

3441706

3441709

3441711

3441712

3441715

3441716

3441719

3441720

3441721

3441724

3441725

3441726

3441727

3441729

3441730

3441731

3441732

3441735

3441736

3441740

3441741

3441742

3441744

3441745

3441746

3441747

3441748

3441749

3441753

3441754

3441759

3441763

3441764

3441766

3441767

3441768

3441769

3441776

3441778

3441779

3441780

3441787

3441788

3441791

3441792

3441793

3441799

3441805

3441807

3441808

3441809

3951539

3951540

3951542

3951543

3951545

3951548

3951549

3951550

3951551

3951555

3951556

3951557

3951558

3951560

3951561

3951562

3951564

3GXB

3HXO

3HXQ

3PPV

3PPW

3PPX

3PPY

3ZQK

48871_at

4C29

4C2A

4C2B

4DMU

4NT5

5BV8

607_s_at

6FWN

72874

72875

7450

7960464

A_21_P0012280

A_23_P105562

A_32_P150382

AAA61293

AAA61294

AAA61295

AAA65940

AAB39987

AAB59458

AAB59512

AAH22258

AC005845

AC005846

AC005904

BC022258

CAA26503

CAA27765

CAA27972

CAA29985

CAB001694

CAB072874

CAB072875

CCDS8539

CH471116

EAW88817

ENSG00000110799

ENSP00000261405

ENST00000261405

ENST00000261405.9

EntrezGene:7450

EntrezGene:VWF

g9257255_3p_at

GE59658

GO:0002020

GO:0002576

GO:0003674

GO:0005178

GO:0005198

GO:0005201

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0006810

GO:0006950

GO:0007155

GO:0007596

GO:0007597

GO:0007599

GO:0008150

GO:0009611

GO:0016192

GO:0019865

GO:0019899

GO:0022607

GO:0030168

GO:0030198

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031589

GO:0033093

GO:0042802

GO:0042803

GO:0043226

GO:0047485

GO:0051087

GO:0051260

GO:0062023

GO:0065003

GO:0070062

HGNC:12726

HPA001815

HPA002082

Hs.110802.1.A1_3p_a_at

I3L4K4

ILMN_1752755

IPR001007

IPR001846

IPR002035

IPR002919

IPR006207

IPR014853

IPR032361

IPR036084

IPR036465

IPR037578

K03028

M10321

M10321_s_at

M16945

M16946

M17588

M25828

M25829

M25830

M25831

M25832

M25833

M25834

M25835

M25836

M25837

M25838

M25839

M25840

M25841

M25842

M25843

M25844

M25845

M25846

M25847

M25848

M25849

M25850

M25851

M25852

M25853

M25854

M25855

M25856

M25857

M25858

M25859

M25860

M25861

M25862

M25863

M25864

M25865

M60675

MIM:193400

MIM:277480

MIM:613160

MIM:613554

NM_000552

NP_000543

PF00092

PF00093

PF00094

PF01826

PF08742

PF16164

PH_hs_0025809

PR00453

SM00041

SM00214

SM00215

SM00216

SM00327

SM00832

TC12001130.hg

TC22001197.hg

U81237

UPI00001AE7EE

VWF

VWF-201

X02672

X04146

X04385

X06828

X06829

Participant Of

hasMember

input

vWF binds to collagen

hasComponent

Collagen type I fibril:vWF [extracellular region]

Other forms of this molecule

VWF(23-763) [platelet alpha granule lumen]

VWF(764-2813) [extracellular region]

Inferred To

Ghost homologue of VWF(23-763) [extracellular region] (Bos taurus)

Ghost homologue of VWF(23-763) [extracellular region] (Rattus norvegicus)

Ghost homologue of VWF(23-763) [extracellular region] (Sus scrofa)

VWF(23-763) [extracellular region] (Danio rerio)

VWF(23-763) [extracellular region] (Dictyostelium discoideum)

VWF(23-763) [extracellular region] (Drosophila melanogaster)

VWF(23-763) [extracellular region] (Gallus gallus)

VWF(23-763) [extracellular region] (Mus musculus)

VWF(23-763) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_000543.2

OpenTargets

ENSG00000110799

GeneCards

P04275

ZINC target

P04275

PRO

P04275

Orphanet

15714

PDB

1IJK, 1OAK, 3HXQ, 2ADF, 1AO3, 1U0N, 3HXO, 1IJB, 4C2B, 3PPX, 3PPY, 5BV8, 3PPW, 1FE8, 1AUQ, 1FNS, 1UEX, 3PPV, 4C2A, 1SQ0, 2MHQ, 3GXB, 1M10, 4C29, 2MHP, 4NT5, 4DMU, 3ZQK, 1ATZ, 6N29, 6FWN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04275 VWF	3	VWF(764-2813) [extracellular region] (R-HSA-158327) VWF(23-763) [platelet alpha granule lumen] (R-HSA-114662) VWF(23-763) [extracellular region] (R-HSA-67271)	0.868	21
UniProt:Q76LX8 ADAMTS13	3	glc-fuc-ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5172961) ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5173292) O-fuc-ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5173286)	0.789	19
UniProt:P07359 GP1BA	1	GP1BA [plasma membrane] (R-HSA-55861)	0.623	2
UniProt:P00451-PRO_0000002967 F8			0.544	2
UniProt:Q96CV9 OPTN	4	p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.508	2