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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
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Developer's Zone
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Citing us
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VWF(23-763) [extracellular region]
Stable Identifier
R-HSA-67271
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
VWF, Von Willebrand factor precursor, vWF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
vWF binds to collagen (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
GP1b signaling involves c-Src (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V binds filamin (Homo sapiens)
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Thrombin binding to GP1b:IX:V (Homo sapiens)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Autophosphorylation of PTK2 at Y397 (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Autophosphorylation of SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Clustering of Integrin alphaIIb beta3 complexes (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dephosphorylation of inactive SRC by PTPB1 (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of GRB2 to p-PTK2 (Homo sapiens)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of pPTK2 by SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Release of CSK from SRC (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Translocation of PTK2 to Focal complexes (Homo sapiens)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Crk binding to p130cas (Homo sapiens)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Recruitment of BCAR1 to PTK2 complex (Homo sapiens)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Homo sapiens)
Focal complex [plasma membrane] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
VWF(23-763) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04275 VWF
Gene Names
VWF, F8VWF
Chain
signal peptide:1-22, chain:23-763, chain:764-2813
Reference Genes
BioGPS Gene:7450 VWF
COSMIC (genes):VWF VWF
CTD Gene:7450 VWF
dbSNP Gene:7450 VWF
ENSEMBL:ENSG00000110799.14 VWF
HGNC:12726 VWF
KEGG Gene (Homo sapiens):7450 VWF
Monarch:7450 VWF
NCBI Gene:7450 VWF
OMIM:613160 VWF
UCSC:P04275 VWF
Reference Transcript
RefSeq:NM_000552.4 VWF
Other Identifiers
11724540_a_at
11724541_s_at
11747176_a_at
11751779_a_at
11752216_a_at
16760257
17123028
17123030
17123032
202112_PM_at
202112_at
233980_PM_s_at
233980_s_at
3441686
3441687
3441688
3441689
3441691
3441693
3441695
3441696
3441699
3441700
3441701
3441702
3441705
3441706
3441709
3441711
3441712
3441715
3441716
3441719
3441720
3441721
3441724
3441725
3441726
3441727
3441729
3441730
3441731
3441732
3441735
3441736
3441740
3441741
3441742
3441744
3441745
3441746
3441747
3441748
3441749
3441753
3441754
3441759
3441763
3441764
3441766
3441767
3441768
3441769
3441776
3441778
3441779
3441780
3441787
3441788
3441791
3441792
3441793
3441799
3441805
3441807
3441808
3441809
3951539
3951540
3951542
3951543
3951545
3951548
3951549
3951550
3951551
3951555
3951556
3951557
3951558
3951560
3951561
3951562
3951564
48871_at
607_s_at
7450
7960464
A_21_P0012280
A_23_P105562
A_32_P150382
GE59658
GO:0002020
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0007155
GO:0007596
GO:0007599
GO:0009611
GO:0019865
GO:0023052
GO:0030168
GO:0030312
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0031589
GO:0033093
GO:0042060
GO:0042802
GO:0043226
GO:0047485
GO:0051087
GO:0062023
GO:0070062
GO:1902533
HMNXSV003045470
Hs.110802.1.A1_3p_a_at
ILMN_1752755
M10321_s_at
PH_hs_0025809
TC12001130.hg
TC22001197.hg
g9257255_3p_at
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Homo sapiens)
as an input of
vWF binds to collagen (Homo sapiens)
as a component of
Collagen type I fibril:vWF [extracellular region] (Homo sapiens)
Other forms of this molecule
VWF(23-763) [platelet alpha granule lumen]
VWF(764-2813) [extracellular region]
Inferred To
Ghost homologue of VWF(23-763) [extracellular region]
(Rattus norvegicus)
VWF(23-763) [extracellular region]
(Canis familiaris)
VWF [extracellular region]
(Bos taurus)
VWF [extracellular region]
(Gallus gallus)
VWF [extracellular region]
(Sus scrofa)
vwf [extracellular region]
(Xenopus tropicalis)
Vwf [extracellular region]
(Mus musculus)
Hml [extracellular region]
(Drosophila melanogaster)
si:ch1073-474e24.1 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000543.2
OpenTargets
ENSG00000110799
GeneCards
P04275
HPA
ENSG00000110799-VWF
ZINC target
P04275
Ensembl
ENSG00000110799
,
ENSP00000261405
,
ENST00000261405
PRO
P04275
Pharos - Targets
P04275
Orphanet
15714
PDB
1SQ0
,
3PPW
,
4C2B
,
3GXB
,
5BV8
,
1AO3
,
2MHQ
,
7F49
,
7PNF
,
3PPX
,
3PPY
,
1M10
,
3ZQK
,
1ATZ
,
7PMV
,
2MHP
,
3PPV
,
1UEX
,
4C2A
,
6N29
,
4DMU
,
1FNS
,
6FWN
,
2ADF
,
4C29
,
4NT5
,
1IJB
,
1U0N
,
1IJK
,
7KWO
,
1AUQ
,
3HXO
,
1OAK
,
1FE8
,
7EOW
,
3HXQ
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04275 VWF
3
VWF(23-763) [platelet alpha granule lumen]
(R-HSA-114662)
VWF(764-2813) [extracellular region]
(R-HSA-158327)
VWF(23-763) [extracellular region]
(R-HSA-67271)
0.868
21
UniProt:Q76LX8 ADAMTS13
3
ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173292)
glc-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5172961)
O-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173286)
0.789
19
UniProt:P00451 F8
20
Factor VIII precursor [extracellular region]
(R-HSA-54601)
Coagulation factor VIII precursor [platelet alpha granule lumen]
(R-HSA-114591)
F8(392-759) D579A [plasma membrane]
(R-HSA-9668364)
F8(392-759) V578A [plasma membrane]
(R-HSA-9668367)
F8(392-759) R546W [plasma membrane]
(R-HSA-9668360)
F8(392-759) S577F [plasma membrane]
(R-HSA-9668362)
F8(392-759) I585T [plasma membrane]
(R-HSA-9668357)
F8 N637S [endoplasmic reticulum lumen]
(R-HSA-9661996)
F8 G2013R [endoplasmic reticulum lumen]
(R-HSA-9666350)
F8 W604R [endoplasmic reticulum lumen]
(R-HSA-9661993)
F8 R1126W [endoplasmic reticulum lumen]
(R-HSA-9662699)
F8 R2326L [endoplasmic reticulum lumen]
(R-HSA-9661995)
F8 P947R [endoplasmic reticulum lumen]
(R-HSA-9662692)
F8 H1066Y [endoplasmic reticulum lumen]
(R-HSA-9662693)
F8 S603G [endoplasmic reticulum lumen]
(R-HSA-9661989)
F8 E1057K [endoplasmic reticulum lumen]
(R-HSA-9662694)
F8 E600D [endoplasmic reticulum lumen]
(R-HSA-9661991)
F8 W604C [endoplasmic reticulum lumen]
(R-HSA-9661984)
F8 D845E [endoplasmic reticulum lumen]
(R-HSA-9662689)
F8 G720S [endoplasmic reticulum lumen]
(R-HSA-9661985)
0.623
2
UniProt:P07359 GP1BA
1
GP1BA [plasma membrane]
(R-HSA-55861)
0.623
2
UniProt:P00451-PRO_0000002967 F8
0.544
2
UniProt:Q96CV9 OPTN
5
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
0.454
2
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![VWF(23-763) [extracellular region] icon](/icon/R-ICO-013525.svg){kind=icon}
