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vWF binds to collagen
Stable Identifier
R-HSA-114671
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
vWF binds to collagen (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'Collagen I', and 1 molecule of 'Von Willebrand factor precursor' are present. At the end of this reaction, 1 molecule of 'Collagen IV : vWF complex' is present.
Literature References
PubMed ID
Title
Journal
Year
3872140
Factor VIII/von Willebrand factor in subendothelium mediates platelet adhesion
Zimmerman, TS
,
Weiss, HJ
,
Sussman, II
,
Turitto, VT
Blood
1985
Participants
Input
Collagen type I fibril [extracellular region]
(Homo sapiens)
VWF(23-763) [extracellular region]
(Homo sapiens)
Output
Collagen type I fibril:vWF [extracellular region]
(Homo sapiens)
Participates
as an event of
GP1b-IX-V activation signalling (Homo sapiens)
Orthologous Events
vWF binds to collagen (Bos taurus)
vWF binds to collagen (Canis familiaris)
vWF binds to collagen (Danio rerio)
vWF binds to collagen (Gallus gallus)
vWF binds to collagen (Mus musculus)
vWF binds to collagen (Sus scrofa)
vWF binds to collagen (Xenopus tropicalis)
Created
Farndale, R (2004-09-25)
Pace, NP (2004-09-25)
de Bono, B (2004-09-25)
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