Reactome | VWF(23-763) [platelet alpha granule lumen]

VWF(23-763) [platelet alpha granule lumen]

Stable Identifier

R-HSA-114662

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Von Willebrand factor precursor, vWF

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External Reference Information

External Reference

UniProt:P04275 VWF

Gene Names

VWF, F8VWF

Chain

signal peptide:1-22, chain:23-763, chain:764-2813

Reference Genes

BioGPS Gene:7450 P042752

COSMIC (genes):VWF VWF

CTD Gene:7450 P042752

dbSNP Gene:7450 P042752

ENSEMBL:ENSG00000110799 VWF

HGNC:12726 P042752

KEGG:hsa:7450 P042752

Monarch:7450 P042752

NCBI Gene:7450 P042752

OMIM:613160 P042752

UCSC:P04275 P042752

Reference Transcript

RefSeq:NM_000552.4 P042752

Participates

as a member of

Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

VWF(23-763) [extracellular region]

VWF(764-2813) [extracellular region]

VWF L1733P (764-2813) [extracellular region]

VWF S1731L (764-2813) [extracellular region]

VWF K1794E (764-2813) [extracellular region]

VWF S1731T (764-2813) [extracellular region]

VWF S1783A (764-2813) [extracellular region]

VWF H1786D (764-2813) [extracellular region]

VWF W1745C (764-2813) [extracellular region]

VWF(764-1605) [extracellular region]

VWF (1606-2813) [extracellular region]

VWF G1579R (764-2813) [extracellular region]

VWF Y1584C (764-2813) [extracellular region]

VWF G1631D (764-2813) [extracellular region]

VWF C1099P (764-2813) [extracellular region]

VWF I1568N (764-2813) [extracellular region]

VWF Y1584C (764-1605) [extracellular region]

VWF G1631D (1606-2813) [extracellular region]

VWF I1568N (764-1605) [extracellular region]

VWF C1099P (764-1605) [extracellular region]

VWF G1579R (764-1605) [extracellular region]

VWF S1358N (764-2813) [extracellular region]

VWF S1387I (764-2813) [extracellular region]

VWF S1394F (764-2813) [extracellular region]

VWF Q1402P (764-2813) [extracellular region]

Inferred To

vwf [platelet alpha granule lumen] (Danio rerio)

vwf [platelet alpha granule lumen] (Xenopus tropicalis)

Homologues of VWF(23-763) [platelet alpha granule lumen] (Canis familiaris)

VWF(23-763) [platelet alpha granule lumen] (Gallus gallus)

Hml [platelet alpha granule lumen] (Drosophila melanogaster)

VWF [platelet alpha granule lumen] (Bos taurus)

VWF [platelet alpha granule lumen] (Canis familiaris)

VWF [platelet alpha granule lumen] (Sus scrofa)

Vwf [platelet alpha granule lumen] (Mus musculus)

Cross References

RefSeq

NP_000543.2

OpenTargets

ENSG00000110799

ENSEMBL

ENST00000261405, ENSP00000261405, ENSG00000110799

GeneCards

VWF

HPA

ENSG00000110799-VWF

ZINC - Substances

VWF_HUMAN

ZINC target

P04275

PRO

P04275

Pharos - Targets

P04275

GlyGen

P04275

Orphanet

VWF

PDB

4C2B, 7KWO, 1M10, 3GXB, 1FE8, 4C2A, 4C29, 5BV8, 1FNS, 1AUQ, 7P4N, 7ZWH, 7EOW, 2ADF, 1U0N, 6N29, 7PNF, 6FWN, 3ZQK, 2MHQ, 2MHP, 7F49, 8D3C, 8D3D, 3PPY, 3PPX, 1IJK, 3PPW, 3PPV, 4NT5, 3HXQ, 7PMV, 1ATZ, 4DMU, 1SQ0, 3HXO, 1IJB, 1AO3, 1UEX, 1OAK

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04275 VWF	20	VWF(23-763) [extracellular region] (R-HSA-67271) VWF(764-2813) [extracellular region] (R-HSA-158327) VWF(23-763) [platelet alpha granule lumen] (R-HSA-114662) VWF L1733P (764-2813) [extracellular region] (R-HSA-9824345) VWF S1731L (764-2813) [extracellular region] (R-HSA-9823681) VWF K1794E (764-2813) [extracellular region] (R-HSA-9823657) VWF S1731T (764-2813) [extracellular region] (R-HSA-9823615) VWF S1783A (764-2813) [extracellular region] (R-HSA-9823588) VWF H1786D (764-2813) [extracellular region] (R-HSA-9823634) VWF W1745C (764-2813) [extracellular region] (R-HSA-9823611) VWF(764-1605) [extracellular region] (R-HSA-9822545) VWF (1606-2813) [extracellular region] (R-HSA-9822534) VWF G1579R (764-2813) [extracellular region] (R-HSA-9844214) VWF Y1584C (764-2813) [extracellular region] (R-HSA-9844202) VWF G1631D (764-2813) [extracellular region] (R-HSA-9844230) VWF C1099P (764-2813) [extracellular region] (R-HSA-9844221) VWF I1568N (764-2813) [extracellular region] (R-HSA-9844203) VWF Y1584C (764-1605) [extracellular region] (R-HSA-9852765) VWF G1631D (1606-2813) [extracellular region] (R-HSA-9852788) VWF I1568N (764-1605) [extracellular region] (R-HSA-9852790)	0.868	21
UniProt:Q76LX8 ADAMTS13	7	glc-fuc-ADAMTS13 [extracellular region] (R-HSA-9822541) ADAMTS13 A250V [extracellular region] (R-HSA-9824393) ADAMTS13 Q449* [extracellular region] (R-HSA-9824391) ADAMTS13 P475S [extracellular region] (R-HSA-9824387) O-fuc-ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5173286) glc-fuc-ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5172961) ADAMTS13 [endoplasmic reticulum lumen] (R-HSA-5173292)	0.789	19
UniProt:P07359 GP1BA	6	GP1BA [plasma membrane] (R-HSA-55861) GP1BA D251Y [plasma membrane] (R-HSA-9844197) GP1BA W246L [plasma membrane] (R-HSA-9844258) GP1BA M255V [plasma membrane] (R-HSA-9844240) GP1BA G249V [plasma membrane] (R-HSA-9844257) GP1BA G249S [plasma membrane] (R-HSA-9844280)	0.623	2
UniProt:P00451 F8	20	F8(392-759) D579A [plasma membrane] (R-HSA-9668364) F8(392-759) V578A [plasma membrane] (R-HSA-9668367) F8(392-759) R546W [plasma membrane] (R-HSA-9668360) F8(392-759) S577F [plasma membrane] (R-HSA-9668362) F8(392-759) I585T [plasma membrane] (R-HSA-9668357) F8 N637S [endoplasmic reticulum lumen] (R-HSA-9661996) F8 G2013R [endoplasmic reticulum lumen] (R-HSA-9666350) F8 W604R [endoplasmic reticulum lumen] (R-HSA-9661993) F8 R1126W [endoplasmic reticulum lumen] (R-HSA-9662699) F8 R2326L [endoplasmic reticulum lumen] (R-HSA-9661995) F8 P947R [endoplasmic reticulum lumen] (R-HSA-9662692) F8 H1066Y [endoplasmic reticulum lumen] (R-HSA-9662693) F8 S603G [endoplasmic reticulum lumen] (R-HSA-9661989) F8 E1057K [endoplasmic reticulum lumen] (R-HSA-9662694) F8 E600D [endoplasmic reticulum lumen] (R-HSA-9661991) F8 W604C [endoplasmic reticulum lumen] (R-HSA-9661984) F8 D845E [endoplasmic reticulum lumen] (R-HSA-9662689) F8 G720S [endoplasmic reticulum lumen] (R-HSA-9661985) F8 E600Q [endoplasmic reticulum lumen] (R-HSA-9662015) F8 R2326Q [endoplasmic reticulum lumen] (R-HSA-9661945)	0.623	2
UniProt:P00451-PRO_0000002967 F8			0.544	2
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.454	2

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