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VWF(23-763) [platelet alpha granule lumen]
Stable Identifier
R-HSA-114662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
Von Willebrand factor precursor, vWF
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
VWF(23-763) [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04275 VWF
Gene Names
VWF, F8VWF
Chain
signal peptide:1-22, chain:23-763, chain:764-2813
Reference Genes
BioGPS Gene:7450 P042752
COSMIC (genes):VWF VWF
CTD Gene:7450 P042752
dbSNP Gene:7450 P042752
ENSEMBL:ENSG00000110799 VWF
HGNC:12726 P042752
KEGG:hsa:7450 P042752
Monarch:7450 P042752
NCBI Gene:7450 P042752
OMIM:613160 P042752
UCSC:P04275 P042752
Reference Transcript
RefSeq:NM_000552.4 P042752
Participates
as a member of
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
VWF(23-763) [extracellular region]
VWF(764-2813) [extracellular region]
VWF L1733P (764-2813) [extracellular region]
VWF S1731L (764-2813) [extracellular region]
VWF K1794E (764-2813) [extracellular region]
VWF S1731T (764-2813) [extracellular region]
VWF S1783A (764-2813) [extracellular region]
VWF H1786D (764-2813) [extracellular region]
VWF W1745C (764-2813) [extracellular region]
VWF(764-1605) [extracellular region]
VWF (1606-2813) [extracellular region]
VWF G1579R (764-2813) [extracellular region]
VWF Y1584C (764-2813) [extracellular region]
VWF G1631D (764-2813) [extracellular region]
VWF C1099P (764-2813) [extracellular region]
VWF I1568N (764-2813) [extracellular region]
VWF Y1584C (764-1605) [extracellular region]
VWF G1631D (1606-2813) [extracellular region]
VWF I1568N (764-1605) [extracellular region]
VWF C1099P (764-1605) [extracellular region]
VWF G1579R (764-1605) [extracellular region]
VWF S1358N (764-2813) [extracellular region]
VWF S1387I (764-2813) [extracellular region]
VWF S1394F (764-2813) [extracellular region]
VWF Q1402P (764-2813) [extracellular region]
Inferred To
vwf [platelet alpha granule lumen]
(Danio rerio)
vwf [platelet alpha granule lumen]
(Xenopus tropicalis)
Homologues of VWF(23-763) [platelet alpha granule lumen]
(Canis familiaris)
VWF(23-763) [platelet alpha granule lumen]
(Gallus gallus)
Hml [platelet alpha granule lumen]
(Drosophila melanogaster)
VWF [platelet alpha granule lumen]
(Bos taurus)
VWF [platelet alpha granule lumen]
(Canis familiaris)
VWF [platelet alpha granule lumen]
(Sus scrofa)
Vwf [platelet alpha granule lumen]
(Mus musculus)
Cross References
RefSeq
NP_000543.2
OpenTargets
ENSG00000110799
ENSEMBL
ENST00000261405
,
ENSP00000261405
,
ENSG00000110799
GeneCards
VWF
HPA
ENSG00000110799-VWF
ZINC - Substances
VWF_HUMAN
ZINC target
P04275
PRO
P04275
Pharos - Targets
P04275
GlyGen
P04275
Orphanet
VWF
PDB
4C2B
,
7KWO
,
1M10
,
3GXB
,
1FE8
,
4C2A
,
4C29
,
5BV8
,
1FNS
,
1AUQ
,
7P4N
,
7ZWH
,
7EOW
,
2ADF
,
1U0N
,
6N29
,
7PNF
,
6FWN
,
3ZQK
,
2MHQ
,
2MHP
,
7F49
,
8D3C
,
8D3D
,
3PPY
,
3PPX
,
1IJK
,
3PPW
,
3PPV
,
4NT5
,
3HXQ
,
7PMV
,
1ATZ
,
4DMU
,
1SQ0
,
3HXO
,
1IJB
,
1AO3
,
1UEX
,
1OAK
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04275 VWF
20
VWF(23-763) [extracellular region]
(R-HSA-67271)
VWF(764-2813) [extracellular region]
(R-HSA-158327)
VWF(23-763) [platelet alpha granule lumen]
(R-HSA-114662)
VWF L1733P (764-2813) [extracellular region]
(R-HSA-9824345)
VWF S1731L (764-2813) [extracellular region]
(R-HSA-9823681)
VWF K1794E (764-2813) [extracellular region]
(R-HSA-9823657)
VWF S1731T (764-2813) [extracellular region]
(R-HSA-9823615)
VWF S1783A (764-2813) [extracellular region]
(R-HSA-9823588)
VWF H1786D (764-2813) [extracellular region]
(R-HSA-9823634)
VWF W1745C (764-2813) [extracellular region]
(R-HSA-9823611)
VWF(764-1605) [extracellular region]
(R-HSA-9822545)
VWF (1606-2813) [extracellular region]
(R-HSA-9822534)
VWF G1579R (764-2813) [extracellular region]
(R-HSA-9844214)
VWF Y1584C (764-2813) [extracellular region]
(R-HSA-9844202)
VWF G1631D (764-2813) [extracellular region]
(R-HSA-9844230)
VWF C1099P (764-2813) [extracellular region]
(R-HSA-9844221)
VWF I1568N (764-2813) [extracellular region]
(R-HSA-9844203)
VWF Y1584C (764-1605) [extracellular region]
(R-HSA-9852765)
VWF G1631D (1606-2813) [extracellular region]
(R-HSA-9852788)
VWF I1568N (764-1605) [extracellular region]
(R-HSA-9852790)
0.868
21
UniProt:Q76LX8 ADAMTS13
7
glc-fuc-ADAMTS13 [extracellular region]
(R-HSA-9822541)
ADAMTS13 A250V [extracellular region]
(R-HSA-9824393)
ADAMTS13 Q449* [extracellular region]
(R-HSA-9824391)
ADAMTS13 P475S [extracellular region]
(R-HSA-9824387)
O-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173286)
glc-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5172961)
ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173292)
0.789
19
UniProt:P07359 GP1BA
6
GP1BA [plasma membrane]
(R-HSA-55861)
GP1BA D251Y [plasma membrane]
(R-HSA-9844197)
GP1BA W246L [plasma membrane]
(R-HSA-9844258)
GP1BA M255V [plasma membrane]
(R-HSA-9844240)
GP1BA G249V [plasma membrane]
(R-HSA-9844257)
GP1BA G249S [plasma membrane]
(R-HSA-9844280)
0.623
2
UniProt:P00451 F8
20
F8(392-759) D579A [plasma membrane]
(R-HSA-9668364)
F8(392-759) V578A [plasma membrane]
(R-HSA-9668367)
F8(392-759) R546W [plasma membrane]
(R-HSA-9668360)
F8(392-759) S577F [plasma membrane]
(R-HSA-9668362)
F8(392-759) I585T [plasma membrane]
(R-HSA-9668357)
F8 N637S [endoplasmic reticulum lumen]
(R-HSA-9661996)
F8 G2013R [endoplasmic reticulum lumen]
(R-HSA-9666350)
F8 W604R [endoplasmic reticulum lumen]
(R-HSA-9661993)
F8 R1126W [endoplasmic reticulum lumen]
(R-HSA-9662699)
F8 R2326L [endoplasmic reticulum lumen]
(R-HSA-9661995)
F8 P947R [endoplasmic reticulum lumen]
(R-HSA-9662692)
F8 H1066Y [endoplasmic reticulum lumen]
(R-HSA-9662693)
F8 S603G [endoplasmic reticulum lumen]
(R-HSA-9661989)
F8 E1057K [endoplasmic reticulum lumen]
(R-HSA-9662694)
F8 E600D [endoplasmic reticulum lumen]
(R-HSA-9661991)
F8 W604C [endoplasmic reticulum lumen]
(R-HSA-9661984)
F8 D845E [endoplasmic reticulum lumen]
(R-HSA-9662689)
F8 G720S [endoplasmic reticulum lumen]
(R-HSA-9661985)
F8 E600Q [endoplasmic reticulum lumen]
(R-HSA-9662015)
F8 R2326Q [endoplasmic reticulum lumen]
(R-HSA-9661945)
0.623
2
UniProt:P00451-PRO_0000002967 F8
0.544
2
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.454
2
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