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VWF(764-1605) [extracellular region]
Stable Identifier
R-HSA-9822545
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
von Willebrand factor(764-1605), vWF
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of platelet adhesion to exposed collagen (Homo sapiens)
Enhanced cleavage of VWF variant by ADAMTS13 (Homo sapiens)
ADAMTS13 cleaves VWF variant multimer (Homo sapiens)
Collagen type I fibril:cleaved VWF variant multimer [extracellular region] (Homo sapiens)
Cleaved VWF variants with increased susceptibility to proteolysis [extracellular region] (Homo sapiens)
Cleaved VWF G1631D multimer [extracellular region] (Homo sapiens)
VWF G1631 multimer:VWF (764-1605) [extracellular region] (Homo sapiens)
VWF(764-1605) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
ADAMTS13 cleaves VWF multimer (Homo sapiens)
Collagen type I fibril:cleaved VWF multimer [extracellular region] (Homo sapiens)
cleaved VWF multimer [extracellular region] (Homo sapiens)
VWF multimer:VWF(764-1605) [extracellular region] (Homo sapiens)
VWF(764-1605) [extracellular region] (Homo sapiens)
GPIb:IX:V binds to VWF multimer:collagen (Homo sapiens)
Collagen type I fibril:cleaved VWF multimer [extracellular region] (Homo sapiens)
cleaved VWF multimer [extracellular region] (Homo sapiens)
VWF multimer:VWF(764-1605) [extracellular region] (Homo sapiens)
VWF(764-1605) [extracellular region] (Homo sapiens)
cleaved VWF multimer [extracellular region] (Homo sapiens)
VWF multimer:VWF(764-1605) [extracellular region] (Homo sapiens)
VWF(764-1605) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04275 VWF
Gene Names
VWF, F8VWF
Chain
signal peptide:1-22, chain:23-763, chain:764-2813
Reference Genes
BioGPS Gene:7450 VWF
COSMIC (genes):VWF VWF
CTD Gene:7450 VWF
dbSNP Gene:7450 VWF
ENSEMBL:ENSG00000110799 VWF
ENSEMBL_homo_sapiens_GENE:ENSG00000110799.14 VWF
HGNC:12726 VWF
KEGG Gene (Homo sapiens):7450 VWF
Monarch:7450 VWF
NCBI Gene:7450 VWF
OMIM:613160 VWF
UCSC:P04275 VWF
Reference Transcript
RefSeq:NM_000552.4 VWF
Other Identifiers
11724540_a_at
11724541_s_at
11747176_a_at
11751779_a_at
11752216_a_at
16760257
17123028
17123030
17123032
202112_PM_at
202112_at
233980_PM_s_at
233980_s_at
3441686
3441687
3441688
3441689
3441691
3441693
3441695
3441696
3441699
3441700
3441701
3441702
3441705
3441706
3441709
3441711
3441712
3441715
3441716
3441719
3441720
3441721
3441724
3441725
3441726
3441727
3441729
3441730
3441731
3441732
3441735
3441736
3441740
3441741
3441742
3441744
3441745
3441746
3441747
3441748
3441749
3441753
3441754
3441759
3441763
3441764
3441766
3441767
3441768
3441769
3441776
3441778
3441779
3441780
3441787
3441788
3441791
3441792
3441793
3441799
3441805
3441807
3441808
3441809
3951539
3951540
3951542
3951543
3951545
3951548
3951549
3951550
3951551
3951555
3951556
3951557
3951558
3951560
3951561
3951562
3951564
48871_at
607_s_at
7450
7960464
A_21_P0012280
A_23_P105562
A_32_P150382
GE59658
GO:0002020
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005783
GO:0007155
GO:0007596
GO:0007599
GO:0009611
GO:0019865
GO:0023052
GO:0030168
GO:0030312
GO:0031012
GO:0031091
GO:0031093
GO:0031410
GO:0031589
GO:0033093
GO:0042060
GO:0042802
GO:0043226
GO:0051087
GO:0062023
GO:0070062
GO:1902533
HMNXSV003045470
Hs.110802.1.A1_3p_a_at
ILMN_1752755
M10321_s_at
PH_hs_0025809
TC12001130.hg
TC22001197.hg
g9257255_3p_at
Participates
as a component of
VWF G1631 multimer:VWF (764-1605) [extracellular region] (Homo sapiens)
VWF multimer:VWF(764-1605) [extracellular region] (Homo sapiens)
Other forms of this molecule
VWF(23-763) [platelet alpha granule lumen]
VWF Q1402P (764-2813) [extracellular region]
VWF S1394F (764-2813) [extracellular region]
VWF S1387I (764-2813) [extracellular region]
VWF S1358N (764-2813) [extracellular region]
VWF G1579R (764-1605) [extracellular region]
VWF C1099P (764-1605) [extracellular region]
VWF I1568N (764-1605) [extracellular region]
VWF G1631D (1606-2813) [extracellular region]
VWF Y1584C (764-1605) [extracellular region]
VWF I1568N (764-2813) [extracellular region]
VWF C1099P (764-2813) [extracellular region]
VWF G1631D (764-2813) [extracellular region]
VWF Y1584C (764-2813) [extracellular region]
VWF G1579R (764-2813) [extracellular region]
VWF (1606-2813) [extracellular region]
VWF W1745C (764-2813) [extracellular region]
VWF H1786D (764-2813) [extracellular region]
VWF S1783A (764-2813) [extracellular region]
VWF S1731T (764-2813) [extracellular region]
VWF K1794E (764-2813) [extracellular region]
VWF S1731L (764-2813) [extracellular region]
VWF L1733P (764-2813) [extracellular region]
VWF(764-2813) [extracellular region]
VWF(23-763) [extracellular region]
Inferred To
VWF [extracellular region]
(Bos taurus)
VWF [extracellular region]
(Canis familiaris)
VWF [extracellular region]
(Sus scrofa)
vwf [extracellular region]
(Danio rerio)
vwf [extracellular region]
(Xenopus tropicalis)
VWF(764-1605) [extracellular region]
(Gallus gallus)
Vwf [extracellular region]
(Mus musculus)
Homologues of VWF(764-1605) [extracellular region]
(Canis familiaris)
Cross References
RefSeq
NP_000543.2
OpenTargets
ENSG00000110799
GeneCards
P04275
HPA
ENSG00000110799-VWF
ZINC target
P04275
Ensembl
ENST00000261405
,
ENSG00000110799
,
ENSP00000261405
PRO
P04275
Pharos - Targets
P04275
Orphanet
15714
PDB
7PMV
,
3PPY
,
5BV8
,
7F49
,
1M10
,
3PPX
,
1IJB
,
1FNS
,
4C2B
,
1UEX
,
2MHP
,
3PPW
,
1ATZ
,
4C2A
,
7P4N
,
3PPV
,
2MHQ
,
3GXB
,
1SQ0
,
7PNF
,
1AO3
,
3ZQK
,
4C29
,
4NT5
,
6N29
,
6FWN
,
7KWO
,
1U0N
,
4DMU
,
7EOW
,
8D3C
,
1OAK
,
1FE8
,
8D3D
,
2ADF
,
1AUQ
,
3HXQ
,
1IJK
,
3HXO
,
7ZWH
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04275 VWF
20
VWF(23-763) [platelet alpha granule lumen]
(R-HSA-114662)
VWF Q1402P (764-2813) [extracellular region]
(R-HSA-9823711)
VWF S1394F (764-2813) [extracellular region]
(R-HSA-9823696)
VWF S1387I (764-2813) [extracellular region]
(R-HSA-9823697)
VWF S1358N (764-2813) [extracellular region]
(R-HSA-9823703)
VWF G1579R (764-1605) [extracellular region]
(R-HSA-9852786)
VWF C1099P (764-1605) [extracellular region]
(R-HSA-9852778)
VWF I1568N (764-1605) [extracellular region]
(R-HSA-9852790)
VWF G1631D (1606-2813) [extracellular region]
(R-HSA-9852788)
VWF Y1584C (764-1605) [extracellular region]
(R-HSA-9852765)
VWF I1568N (764-2813) [extracellular region]
(R-HSA-9844203)
VWF C1099P (764-2813) [extracellular region]
(R-HSA-9844221)
VWF G1631D (764-2813) [extracellular region]
(R-HSA-9844230)
VWF Y1584C (764-2813) [extracellular region]
(R-HSA-9844202)
VWF G1579R (764-2813) [extracellular region]
(R-HSA-9844214)
VWF (1606-2813) [extracellular region]
(R-HSA-9822534)
VWF(764-1605) [extracellular region]
(R-HSA-9822545)
VWF W1745C (764-2813) [extracellular region]
(R-HSA-9823611)
VWF H1786D (764-2813) [extracellular region]
(R-HSA-9823634)
VWF S1783A (764-2813) [extracellular region]
(R-HSA-9823588)
0.868
21
UniProt:Q76LX8 ADAMTS13
7
ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173292)
glc-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5172961)
O-fuc-ADAMTS13 [endoplasmic reticulum lumen]
(R-HSA-5173286)
ADAMTS13 P475S [extracellular region]
(R-HSA-9824387)
ADAMTS13 Q449* [extracellular region]
(R-HSA-9824391)
ADAMTS13 A250V [extracellular region]
(R-HSA-9824393)
glc-fuc-ADAMTS13 [extracellular region]
(R-HSA-9822541)
0.789
19
UniProt:P07359 GP1BA
6
GP1BA G249S [plasma membrane]
(R-HSA-9844280)
GP1BA G249V [plasma membrane]
(R-HSA-9844257)
GP1BA M255V [plasma membrane]
(R-HSA-9844240)
GP1BA [plasma membrane]
(R-HSA-55861)
GP1BA D251Y [plasma membrane]
(R-HSA-9844197)
GP1BA W246L [plasma membrane]
(R-HSA-9844258)
0.623
2
UniProt:P00451 F8
20
Factor VIII precursor [extracellular region]
(R-HSA-54601)
Coagulation factor VIII precursor [platelet alpha granule lumen]
(R-HSA-114591)
F8(392-759) D579A [plasma membrane]
(R-HSA-9668364)
F8(392-759) V578A [plasma membrane]
(R-HSA-9668367)
F8(392-759) R546W [plasma membrane]
(R-HSA-9668360)
F8(392-759) S577F [plasma membrane]
(R-HSA-9668362)
F8(392-759) I585T [plasma membrane]
(R-HSA-9668357)
F8 N637S [endoplasmic reticulum lumen]
(R-HSA-9661996)
F8 G2013R [endoplasmic reticulum lumen]
(R-HSA-9666350)
F8 W604R [endoplasmic reticulum lumen]
(R-HSA-9661993)
F8 R1126W [endoplasmic reticulum lumen]
(R-HSA-9662699)
F8 R2326L [endoplasmic reticulum lumen]
(R-HSA-9661995)
F8 P947R [endoplasmic reticulum lumen]
(R-HSA-9662692)
F8 H1066Y [endoplasmic reticulum lumen]
(R-HSA-9662693)
F8 S603G [endoplasmic reticulum lumen]
(R-HSA-9661989)
F8 E1057K [endoplasmic reticulum lumen]
(R-HSA-9662694)
F8 E600D [endoplasmic reticulum lumen]
(R-HSA-9661991)
F8 W604C [endoplasmic reticulum lumen]
(R-HSA-9661984)
F8 D845E [endoplasmic reticulum lumen]
(R-HSA-9662689)
F8 G720S [endoplasmic reticulum lumen]
(R-HSA-9661985)
0.623
2
UniProt:P00451-PRO_0000002967 F8
0.544
2
UniProt:Q96CV9 OPTN
6
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [cytosol]
(R-HSA-9687907)
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
0.454
2
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