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PPP3CB [cytosol]
Stable Identifier
R-HSA-2025869
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, PP2BB_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
ROBO receptors bind AKAP5 (Homo sapiens)
AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
ROBO2:AKAP5:PPP3CB [plasma membrane] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin binds NFATC1,2,3 (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
Inactive catalytic PP2B is activated by the binding of calmodulin (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
PP2B catalytic (Fe3+, Zn2+) [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
PPP3 complex [cytosol] (Homo sapiens)
PPP3CA,B,C:Fe3+:Zn2+:4xCa2+:CaM [cytosol] (Homo sapiens)
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
PPP3CA,B:Calmodulin [cytosol] (Homo sapiens)
PPP3CA,B:Fe3+:Zn2+ [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
PPP3CB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16298 PPP3CB
Gene Names
PPP3CB, CALNA2, CALNB, CNA2
Chain
initiator methionine:, chain:2-524
Reference Genes
BioGPS Gene:5532 PPP3CB
COSMIC (genes):PPP3CB PPP3CB
CTD Gene:5532 PPP3CB
dbSNP Gene:5532 PPP3CB
ENSEMBL:ENSG00000107758 PPP3CB
HGNC:9315 PPP3CB
KEGG:hsa:5532 PPP3CB
Monarch:5532 PPP3CB
NCBI Gene:5532 PPP3CB
OMIM:114106 PPP3CB
UCSC:P16298 PPP3CB
Reference Transcript
RefSeq:NM_001289969.1 PPP3CB
RefSeq:NM_001289968.1 PPP3CB
RefSeq:NM_021132.3 PPP3CB
RefSeq:NM_001142354.2 PPP3CB
RefSeq:NM_001142353.2 PPP3CB
Other Identifiers
11717221_s_at
11748282_a_at
11760342_a_at
11761497_a_at
16715505
202432_PM_at
202432_at
209817_PM_at
209817_at
3294330
3294498
3294500
3294501
3294502
3294503
3294504
3294507
3294509
3294510
3294511
3294512
3294513
3294514
3294515
3294516
3294517
3294518
3294519
3294521
3294522
3294523
3294525
3294526
3294528
3294530
3294531
3294532
3294533
3294534
3294535
38277_at
39780_at
54349_at
5532
63258_at
7934393
A_24_P98524
A_33_P3397399
GE57908
GE63309
GO:0001913
GO:0001915
GO:0001946
GO:0002376
GO:0003824
GO:0004721
GO:0004722
GO:0004723
GO:0005509
GO:0005515
GO:0005516
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005955
GO:0006355
GO:0006468
GO:0006470
GO:0006950
GO:0007165
GO:0007507
GO:0007612
GO:0007613
GO:0008287
GO:0010468
GO:0016192
GO:0016311
GO:0016787
GO:0017018
GO:0017156
GO:0019899
GO:0023057
GO:0030018
GO:0030154
GO:0030217
GO:0030315
GO:0030346
GO:0031987
GO:0033173
GO:0033192
GO:0034097
GO:0035774
GO:0042098
GO:0042110
GO:0043029
GO:0045893
GO:0045944
GO:0046872
GO:0046983
GO:0048167
GO:0048675
GO:0048741
GO:0048856
GO:0050796
GO:0050877
GO:0070886
GO:0097720
GO:0098978
GO:0140096
GO:1900182
GO:1900242
GO:1905665
GO:1905673
GO:1905949
HMNXSV003021486
HMNXSV003039313
HMNXSV003043318
ILMN_1802669
M29550_at
M29551_at
PH_hs_0022890
TC10001410.hg
g11036639_3p_at
g180706_3p_at
Participates
as a component of
ROBO2:AKAP5:PPP3CB [plasma membrane] (Homo sapiens)
as an input of
AKAP5 recruits PPP3CB (PP2BB) to ROBO2 (Homo sapiens)
as a member of
PPP3CA,B,C [cytosol] (Homo sapiens)
PPP3CA,B [cytosol] (Homo sapiens)
Other forms of this molecule
PPP3CB [nucleoplasm]
Inferred To
Homologues of PPP3CB [cytosol]
(Drosophila melanogaster)
Homologues of PPP3CB [cytosol]
(Saccharomyces cerevisiae)
PPP3CB [cytosol]
(Bos taurus)
PPP3CB [cytosol]
(Caenorhabditis elegans)
PPP3CB [cytosol]
(Canis familiaris)
PPP3CB [cytosol]
(Dictyostelium discoideum)
PPP3CB [cytosol]
(Drosophila melanogaster)
PPP3CB [cytosol]
(Gallus gallus)
PPP3CB [cytosol]
(Mus musculus)
PPP3CB [cytosol]
(Plasmodium falciparum)
PPP3CB [cytosol]
(Rattus norvegicus)
PPP3CB [cytosol]
(Saccharomyces cerevisiae)
PPP3CB [cytosol]
(Schizosaccharomyces pombe)
PPP3CB [cytosol]
(Sus scrofa)
ppp3cc [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001276898.1
,
NP_066955.1
,
NP_001135826.1
,
NP_001135825.1
,
NP_001276897.1
ZINC - Investigational
PP2BB_HUMAN
ENSEMBL
ENST00000394828
,
ENSP00000353881
,
ENST00000394829
,
ENSP00000378305
,
ENSP00000378306
,
ENST00000360663
OpenTargets
ENSG00000107758
HPA
ENSG00000107758-PPP3CB
ZINC - Substances
PP2BB_HUMAN
ZINC target
P16298
PRO
P16298
Pharos - Targets
P16298
ZINC - Predictions - Purchasable
PP2BB_HUMAN
HMDB Protein
HMDBP07949
PDB
4OR9
,
4ORC
,
4ORA
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53805 RCAN1
0.547
3
UniProt:Q99J34 Q99J34
0.499
2
UniProt:P14316 IRF2
2
IRF2 [cytosol]
(R-HSA-1015681)
IRF2 [nucleoplasm]
(R-HSA-994031)
0.499
2
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