Reactome | MAPK4 [nucleoplasm]

MAPK4 [nucleoplasm]

Stable Identifier

R-HSA-5686975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ERK4, PRKM4

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External Reference Information

External Reference

UniProt:P31152 MAPK4

Gene Names

MAPK4, ERK4, PRKM4

Chain

chain:1-587

Reference Genes

BioGPS Gene:5596 MAPK4

COSMIC (genes):MAPK4 MAPK4

CTD Gene:5596 MAPK4

dbSNP Gene:5596 MAPK4

ENSEMBL:ENSG00000141639 MAPK4

HGNC:6878 MAPK4

KEGG Gene (Homo sapiens):5596 MAPK4

Monarch:5596 MAPK4

NCBI Gene:5596 MAPK4

OMIM:176949 MAPK4

UCSC:P31152 MAPK4

Reference Transcript

Other Identifiers

11723181_a_at

11751129_a_at

16852322

204707_s_at

3788098

3788099

3788107

3788108

3788109

3788110

3788111

3788135

3788140

3788142

3788144

3788145

3788146

3788147

3788148

3788149

3788150

3788151

3788152

3788153

3788154

3788155

3788156

5596

8021199

997_at

A_14_P122275

A_33_P3307337

GE61712

GO:0000165

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0007049

GO:0007165

GO:0008150

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0035556

GO:0042803

GO:0043167

GO:0043226

GO:0046982

GO:0106310

GO:0106311

HMNXSV003012056

Hs.269222.0.A1_3p_a_at

ILMN_1669620

ILMN_2112128

PH_hs_0025291

TC18000179.hg

g6715608_3p_a_at

Participates

as a member of

MAPK6,4 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MAPK4 [cytosol]

p-S186 MAPK4 [nucleoplasm]

p-S186 MAPK4 [cytosol]

Inferred To

erkA [nucleoplasm] (Dictyostelium discoideum)

mapk6 [nucleoplasm] (Danio rerio)

SMK1 [nucleoplasm] (Saccharomyces cerevisiae)

MAPK4 [nucleoplasm] (Bos taurus)

MAPK4 [nucleoplasm] (Canis familiaris)

MAPK4 [nucleoplasm] (Dictyostelium discoideum)

MAPK4 [nucleoplasm] (Plasmodium falciparum)

MAPK4 [nucleoplasm] (Sus scrofa)

mapk4 [nucleoplasm] (Danio rerio)

mapk4 [nucleoplasm] (Xenopus tropicalis)

Homologues of MAPK4 [nucleoplasm] (Danio rerio)

Homologues of MAPK4 [nucleoplasm] (Dictyostelium discoideum)

Mapk4 [nucleoplasm] (Mus musculus)

Mapk4 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_011524376.1, NP_001278968.1, XP_011524377.1, XP_005258356.1, XP_016881328.1, NP_002738.2, NP_001278969.1, XP_011524378.1

ZINC - World Drugs

MK04_HUMAN

Guide to Pharmacology - Targets

2091

OpenTargets

ENSG00000141639

ZINC - FDA approved

MK04_HUMAN

ZINC - Substances

MK04_HUMAN

ZINC target

P31152

ZINC - Biogenic

MK04_HUMAN

PRO

P31152

ZINC - Investigational

MK04_HUMAN

HPA

ENSG00000141639-MAPK4

GeneCards

P31152

Ensembl

ENSP00000383234, ENSG00000141639, ENST00000400384

Pharos - Targets

P31152

ZINC - Predictions - Purchasable

MK04_HUMAN

HMDB Protein

HMDBP01483

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.641	3
UniProt:Q01813 PFKP	1	PFKP [cytosol] (R-HSA-71452)	0.527	2
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.527	2
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018) MAPKAPK5 [nucleoplasm] (R-HSA-2562517)	0.527	3
UniProt:Q8IUD2 RB6I2			0.527	2
UniProt:Q7L8L6 FAKD5			0.527	2

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