Reactome | p-S186 MAPK4 [cytosol]

p-S186 MAPK4 [cytosol]

Stable Identifier

R-HSA-5687023

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ERK4, PRKM4

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External Reference Information

External Reference

UniProt:P31152 MAPK4

Gene Names

MAPK4, ERK4, PRKM4

Chain

chain:1-587

Reference Genes

BioGPS Gene:5596 MAPK4

COSMIC (genes):MAPK4 MAPK4

CTD Gene:5596 MAPK4

dbSNP Gene:5596 MAPK4

ENSEMBL:ENSG00000141639 MAPK4

HGNC:6878 MAPK4

Monarch:5596 MAPK4

NCBI Gene:5596 MAPK4

OMIM:176949 MAPK4

UCSC:P31152 MAPK4

Reference Transcript

Other Identifiers

11723181_a_at

11751129_a_at

16852322

204707_PM_s_at

204707_s_at

3788098

3788099

3788100

3788107

3788108

3788109

3788110

3788111

3788116

3788123

3788124

3788125

3788126

3788127

3788135

3788140

3788142

3788144

3788145

3788146

3788147

3788148

3788149

3788150

3788151

3788152

3788153

3788154

3788155

3788156

5596

8021199

997_at

A_14_P122275

A_33_P3289860

A_33_P3307337

GE61712

GO:0000165

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006468

GO:0016301

GO:0016740

GO:0019901

GO:0035556

GO:0042803

GO:0043226

GO:0046982

GO:0106310

GO:0140096

HMNXSV003012056

HMNXSV003045922

Hs.269222.0.A1_3p_a_at

ILMN_1669620

ILMN_2112128

PH_hs_0025291

TC18000179.hg

g6715608_3p_a_at

Participates

as a member of

p-S MAPK6,4 [cytosol] (Homo sapiens)

Other forms of this molecule

MAPK4 [nucleoplasm]

MAPK4 [cytosol]

p-S186 MAPK4 [nucleoplasm]

Inferred To

Homologues of p-S186 MAPK4 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-S186 MAPK4 [cytosol] (Schizosaccharomyces pombe)

phospho-MAPK4 [cytosol] (Canis familiaris)

phospho-p-S186 MAPK4 [cytosol] (Bos taurus)

phospho-p-S186 MAPK4 [cytosol] (Caenorhabditis elegans)

phospho-p-S186 MAPK4 [cytosol] (Danio rerio)

phospho-p-S186 MAPK4 [cytosol] (Dictyostelium discoideum)

phospho-p-S186 MAPK4 [cytosol] (Mus musculus)

phospho-p-S186 MAPK4 [cytosol] (Plasmodium falciparum)

phospho-p-S186 MAPK4 [cytosol] (Rattus norvegicus)

phospho-p-S186 MAPK4 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S186 MAPK4 [cytosol] (Schizosaccharomyces pombe)

phospho-p-S186 MAPK4 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 186

Coordinate

186

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ZINC - World Drugs

MK04_HUMAN

Guide to Pharmacology - Targets

2091

ENSEMBL

ENSP00000383234

OpenTargets

ENSG00000141639

ZINC - FDA approved

MK04_HUMAN

ZINC - Substances

MK04_HUMAN

ZINC - Biogenic

MK04_HUMAN

ZINC target

P31152

PRO

P31152

ZINC - Investigational

MK04_HUMAN

HPA

ENSG00000141639-MAPK4

Pharos - Targets

P31152

ZINC - Predictions - Purchasable

MK04_HUMAN

HMDB Protein

HMDBP01483

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.643	4
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018) MAPKAPK5 [nucleoplasm] (R-HSA-2562517)	0.643	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.641	3
UniProt:Q01813 PFKP	1	PFKP [cytosol] (R-HSA-71452)	0.527	2
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.527	2
UniProt:Q8IUD2 RB6I2			0.527	2
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.527	3
UniProt:Q7Z736 PKHH3			0.527	3
UniProt:Q96HN2 AHCYL2	1	AHCYL2 [cytosol] (R-HSA-8878665)	0.527	3

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