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SRF [nucleoplasm]
Stable Identifier
R-HSA-5666000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serum response factor
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
Expression of SRF in cardiogenesis (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
Regulation of NPAS4 gene expression (Homo sapiens)
Regulation of NPAS4 gene transcription (Homo sapiens)
SRF binds NPAS4 gene promoter (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:NPAS4 gene [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF stimulates NPAS4 gene transcription (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:NPAS4 gene [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
E2-mediated FOS gene expression (Homo sapiens)
FOS gene:SRF:p-4S,T336 ELK1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF and ELK1 bind the FOS gene (Homo sapiens)
FOS gene:SRF:p-4S,T336 ELK1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
ARC gene expression (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-S133-CREB1:MEF2D:SRF:ARC gene [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression (Homo sapiens)
p-4S, T336 ELK1:SRF [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF:EGR1,EGR2 genes [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SGK phosphorylates SRF (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF:EGR1,EGR2 genes [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-S133 CREB1, MEF2D and SRF bind the ARC gene (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
p-S133-CREB1:MEF2D:SRF:ARC gene [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
MKL1 binds SRF (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SCAI binds SRF:MKL1 (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1:SCAI [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1 binds ITGB1 Gene (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1:ITGB1 Gene [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it (Homo sapiens)
SRF:MKL1:ITGB1 Gene [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
SRF:MKL1:SCAI [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
SRF [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11831 SRF
Gene Names
SRF
Chain
chain:1-508
Reference Genes
BioGPS Gene:6722 SRF
COSMIC (genes):SRF SRF
CTD Gene:6722 SRF
dbSNP Gene:6722 SRF
ENSEMBL:ENSG00000112658 SRF
ENSEMBL_homo_sapiens_GENE:ENSG00000112658.8 SRF
HGNC:11291 SRF
KEGG Gene (Homo sapiens):6722 SRF
Monarch:6722 SRF
NCBI Gene:6722 SRF
OMIM:600589 SRF
UCSC:P11831 SRF
Reference Transcript
RefSeq:NM_003131.3 SRF
RefSeq:NM_001292001.1 SRF
Other Identifiers
11737486_s_at
11746117_a_at
1409_at
17008856
202400_PM_s_at
202400_s_at
202401_PM_s_at
202401_s_at
2907731
2907732
2907733
2907734
2907735
2907736
2907737
2907738
2907739
2907742
2907743
2907745
2907746
2907750
2907751
2907752
2907753
2907755
40109_at
6722
8119712
A_23_P111020
A_24_P337657
A_24_P346277
GE57476
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001228
GO:0001569
GO:0001666
GO:0001701
GO:0001707
GO:0001764
GO:0001829
GO:0001947
GO:0002011
GO:0002042
GO:0002376
GO:0002521
GO:0003012
GO:0003677
GO:0003682
GO:0003700
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006366
GO:0007010
GO:0007015
GO:0007155
GO:0007160
GO:0007369
GO:0007507
GO:0007616
GO:0008285
GO:0008306
GO:0009636
GO:0009725
GO:0010669
GO:0010736
GO:0021766
GO:0022028
GO:0023052
GO:0030036
GO:0030038
GO:0030154
GO:0030155
GO:0030168
GO:0030220
GO:0030336
GO:0030878
GO:0030900
GO:0031175
GO:0031490
GO:0034097
GO:0034330
GO:0035855
GO:0035912
GO:0042060
GO:0042803
GO:0042826
GO:0043149
GO:0043226
GO:0043565
GO:0043589
GO:0045059
GO:0045214
GO:0045597
GO:0045773
GO:0045893
GO:0045944
GO:0045987
GO:0046016
GO:0046716
GO:0046847
GO:0046983
GO:0048513
GO:0048538
GO:0048589
GO:0048666
GO:0048675
GO:0048821
GO:0048856
GO:0048870
GO:0050877
GO:0051091
GO:0051150
GO:0051491
GO:0055003
GO:0060055
GO:0060218
GO:0060261
GO:0060292
GO:0060324
GO:0060347
GO:0060379
GO:0060425
GO:0060532
GO:0060534
GO:0060947
GO:0061029
GO:0061145
GO:0061436
GO:0061629
GO:0070830
GO:0070878
GO:0071333
GO:0090009
GO:0090136
GO:0090398
GO:0098609
GO:0140110
GO:0140297
GO:1900222
GO:1902894
GO:1902895
GO:1990837
HMNXSV003003408
Hs.155321.0.A1_3p_a_at
ILMN_1803398
J03161_at
PH_hs_0025942
TC06000596.hg
g4507204_3p_a_at
Participates
as an output of
Expression of SRF in cardiogenesis (Homo sapiens)
as a component of
SRF:NPAS4 gene [nucleoplasm] (Homo sapiens)
FOS gene:SRF:p-4S,T336 ELK1 [nucleoplasm] (Homo sapiens)
p-4S, T336 ELK1:SRF [nucleoplasm] (Homo sapiens)
p-S133-CREB1:MEF2D:SRF:ARC gene [nucleoplasm] (Homo sapiens)
SRF:MKL1 [nucleoplasm] (Homo sapiens)
as an input of
SRF binds NPAS4 gene promoter (Homo sapiens)
SRF and ELK1 bind the FOS gene (Homo sapiens)
p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters (Homo sapiens)
p-S133 CREB1, MEF2D and SRF bind the ARC gene (Homo sapiens)
SGK phosphorylates SRF (Homo sapiens)
MKL1 binds SRF (Homo sapiens)
Other forms of this molecule
p-S103 SRF [nucleoplasm]
Inferred To
Srf [nucleoplasm]
(Mus musculus)
Srf [nucleoplasm]
(Rattus norvegicus)
MCM1 [nucleoplasm]
(Saccharomyces cerevisiae)
map1 [nucleoplasm]
(Schizosaccharomyces pombe)
bs [nucleoplasm]
(Drosophila melanogaster)
SRF [nucleoplasm]
(Bos taurus)
SRF [nucleoplasm]
(Canis familiaris)
SRF [nucleoplasm]
(Gallus gallus)
SRF [nucleoplasm]
(Sus scrofa)
unc-120 [nucleoplasm]
(Caenorhabditis elegans)
srfB [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_003122.1
,
NP_001278930.1
OpenTargets
ENSG00000112658
HPA
ENSG00000112658-SRF
GeneCards
P11831
Ensembl
ENSP00000265354
,
ENSG00000112658
,
ENST00000265354
PRO
P11831
Pharos - Targets
P11831
PDB
1K6O
,
1SRS
,
1HBX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9ULH7 MRTFB
0.656
3
UniProt:Q969V6 MRTFA
3
monoSUMO1-K499,K576,K624-MKL1 [nucleoplasm]
(R-HSA-3900216)
MKL1 [nucleoplasm]
(R-HSA-3900220)
MKL1 [cytosol]
(R-HSA-5665975)
0.589
2
UniProt:P15173 MYOG
1
MYOG [nucleoplasm]
(R-HSA-445160)
0.527
2
UniProt:P15172 MYOD1
1
MYOD1 [nucleoplasm]
(R-HSA-445441)
0.527
2
UniProt:Q8IZQ8 MYOCD
1
MYOCD [nucleoplasm]
(R-HSA-9735431)
0.524
2
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