p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters

Stable Identifier
R-HSA-9612076
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-4S, T366 ELK1:SRF bind EGR1 and EGR2 gene promoters
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Expression of Early Growth Response (EGR) genes is dependent in part on the presence of upstream serum response elements (SREs) that bind SRF (serum response factor) and its co-activator ELK1 in response to mutiptle stimuli (Quereshi et al, 1991; Alexandre et al, 1991; de Franco et al, 1993; McMahon and Monroe, 1995;Chen et al, 2004; Vickers et al, 2004; Adams et al, 2017; Esnault et al, 2017; reviewed in O'Donovan et al, 1999; Pérez-Cadahía et al, 2011; Pagel and Deindl, 2011).

Literature References
PubMed ID Title Journal Year
22053691 Early growth response 1--a transcription factor in the crossfire of signal transduction cascades

Pagel, JI, Deindl, E

Indian J. Biochem. Biophys. 2011
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM

PLoS ONE 2017
28286024 ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription

Esnault, C, Gualdrini, F, Horswell, S, Kelly, G, Stewart, A, East, P, Matthews, N, Treisman, R

Mol. Cell 2017
1833716 Transactivation of Krox-20 and Krox-24 promoters by the HTLV-1 Tax protein through common regulatory elements

Alexandre, C, Charnay, P, Verrier, B

Oncogene 1991
15542842 Ternary complex factor-serum response factor complex-regulated gene activity is required for cellular proliferation and inhibition of apoptotic cell death

Vickers, ER, Kasza, A, Kurnaz, IA, Seifert, A, Zeef, LA, O'Donnell, A, Hayes, A, Sharrocks, AD

Mol. Cell. Biol. 2004
15449318 Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1

Chen, CC, Lee, WR, Safe, S

J. Cell. Biochem. 2004
8483478 Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate

DeFranco, C, Damon, DH, Endoh, M, Wagner, JA

Mol. Endocrinol. 1993
2040600 v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements

Qureshi, SA, Cao, XM, Sukhatme, VP, Foster, DA

J. Biol. Chem. 1991
21326363 Activation and function of immediate-early genes in the nervous system

Pérez-Cadahía, B, Drobic, B, Davie, JR

Biochem. Cell Biol. 2011
10203854 The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

O'Donovan, KJ, Tourtellotte, WG, Millbrandt, J, Baraban, JM

Trends Neurosci. 1999
7823924 A ternary complex factor-dependent mechanism mediates induction of egr-1 through selective serum response elements following antigen receptor cross-linking in B lymphocytes

McMahon, SB, Monroe, JG

Mol. Cell. Biol. 1995
Participants
Input
Output
Participates
as an event of
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-06-25)
Cite Us!