SRF and ELK1 bind the FOS gene

Stable Identifier
R-HSA-9625479
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SRF and phosphorylated ELK1 bind to sterol response elements (SRE) in the FOS promoter downstream of E2- and growth factor stimulation (Marais et al, 1993; Gille et al, 1995; Duan et al, 2001; reviewed in Treisman, 1995). FOS gene expression downstream of estrogen stimulation occurs in both an ER alpha (ESR1)- and GPER1-dependent fashion (Maggiolini et al, 2004; Vivacqua et al, 2006; Tsai et al, 2013).

Literature References
PubMed ID Title Journal Year
16835357 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30

Maggiolini, M, Musti, AM, Carpino, A, Rago, V, Picard, D, Madeo, A, Bonofiglio, D, Albanito, L, Andó, S, Vivacqua, A

Mol. Pharmacol. 2006
24039841 Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα)

Lin, CY, Hsueh, S, Chao, A, Lin, YJ, Wang, HS, Tsai, CL, Lai, CH, Wang, TH, Wu, HM

PLoS ONE 2013
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Treisman, R, Wynne, J, Marais, R

Cell 1993
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Moomaw, C, Gille, H, Shaw, PE, Cobb, MH, Thomae, O, Slaughter, C, Kortenjann, M

EMBO J 1995
15090535 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells

Maggiolini, M, Musti, AM, Montanaro, D, Sisci, D, Picard, D, Recchia, AG, Andó, S, Fasanella, G, Vivacqua, A, Pezzi, V

J. Biol. Chem. 2004
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Xie, W, Safe, S, Duan, R, Burghardt, RC

J. Biol. Chem. 2001
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