SRF and ELK1 bind the FOS gene

Stable Identifier
R-HSA-9625479
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SRF and phosphorylated ELK1 bind to sterol response elements (SRE) in the FOS promoter downstream of E2- and growth factor stimulation (Marais et al, 1993; Gille et al, 1995; Duan et al, 2001; reviewed in Treisman, 1995). FOS gene expression downstream of estrogen stimulation occurs in both an ER alpha (ESR1)- and GPER1-dependent fashion (Maggiolini et al, 2004; Vivacqua et al, 2006; Tsai et al, 2013).

Literature References
PubMed ID Title Journal Year
15090535 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells

Maggiolini, M, Vivacqua, A, Fasanella, G, Recchia, AG, Sisci, D, Pezzi, V, Montanaro, D, Musti, AM, Picard, D, Andó, S

J. Biol. Chem. 2004
24039841 Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα)

Tsai, CL, Wu, HM, Lin, CY, Lin, YJ, Chao, A, Wang, TH, Hsueh, S, Lai, CH, Wang, HS

PLoS ONE 2013
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Marais, R, Wynne, J, Treisman, R

Cell 1993
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Duan, R, Xie, W, Burghardt, RC, Safe, S

J. Biol. Chem. 2001
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Gille, H, Kortenjann, M, Thomae, O, Moomaw, C, Slaughter, C, Cobb, MH, Shaw, PE

EMBO J 1995
16835357 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30

Vivacqua, A, Bonofiglio, D, Albanito, L, Madeo, A, Rago, V, Carpino, A, Musti, AM, Picard, D, Andó, S, Maggiolini, M

Mol. Pharmacol. 2006
Participants
Participant Of
Authored
Reviewed
Created