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ub-PTCH1 [ciliary membrane]
Stable Identifier
R-HSA-5632517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary membrane
Synonyms
Patched homolog 1, Protein patched homolog 1, PTC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
PTCH is internalized (Homo sapiens)
ub-PTCH1 [ciliary membrane] (Homo sapiens)
SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
ub-PTCH1 [ciliary membrane] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
ub-PTCH1 [ciliary membrane] (Homo sapiens)
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
ub-PTCH1 [ciliary membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13635 PTCH1
Gene Names
PTCH1, PTCH
Chain
chain:1-1447
Reference Genes
BioGPS Gene:5727 PTCH1
COSMIC (genes):PTCH1 PTCH1
CTD Gene:5727 PTCH1
dbSNP Gene:5727 PTCH1
ENSEMBL:ENSG00000185920 PTCH1
HGNC:9585 PTCH1
KEGG:hsa:5727 PTCH1
Monarch:5727 PTCH1
NCBI Gene:5727 PTCH1
OMIM:601309 PTCH1
UCSC:Q13635 PTCH1
Reference Transcript
RefSeq:NM_001083606.1 PTCH1
RefSeq:NM_001083603.1 PTCH1
RefSeq:NM_001083607.1 PTCH1
RefSeq:NM_001083602.1 PTCH1
RefSeq:NM_000264.3 PTCH1
RefSeq:NM_001083604.1 PTCH1
RefSeq:NM_001083605.1 PTCH1
Participates
as an input of
PTCH is internalized (Homo sapiens)
as an output of
SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
as a component of
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
Other forms of this molecule
PTCH1 [ciliary membrane]
ub-PTCH1 [endocytic vesicle membrane]
PTCH1 [plasma membrane]
Inferred To
PTCH1 [ciliary membrane]
(Bos taurus)
PTCH1 [ciliary membrane]
(Canis familiaris)
PTCH1 [ciliary membrane]
(Sus scrofa)
ptc-3 [ciliary membrane]
(Caenorhabditis elegans)
Ptch1 [ciliary membrane]
(Mus musculus)
Ptch1 [ciliary membrane]
(Rattus norvegicus)
ptch1 [ciliary membrane]
(Xenopus tropicalis)
ptc [ciliary membrane]
(Drosophila melanogaster)
ub-PTCH1 [ciliary membrane]
(Gallus gallus)
ptc-1 [ciliary membrane]
(Caenorhabditis elegans)
Homologues of ub-PTCH1 [ciliary membrane]
(Caenorhabditis elegans)
Modified Residues
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
OpenTargets
ENSG00000185920
ENSEMBL
ENSP00000410287
,
ENSP00000332353
,
ENSP00000414823
,
ENSG00000185920
,
ENST00000429896
,
ENST00000331920
,
ENST00000430669
,
ENST00000692981
,
ENSP00000510238
,
ENSP00000389744
,
ENSP00000518556
,
ENST00000437951
,
ENST00000711046
HPA
ENSG00000185920-PTCH1
GeneCards
PTCH1
PRO
Q13635
Pharos - Targets
Q13635
Orphanet
PTCH1
GlyGen
Q13635
PDB
6RTW
,
6N7K
,
6E1H
,
6DMY
,
6RMG
,
6N7G
,
6RVC
,
6OEU
,
6N7H
,
6RTY
,
6RTX
,
6RVD
,
6DMO
,
6OEV
,
6DMB
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21146
4
phospho-p-S29-ADRBK1 [cytosol]
(R-BTA-9645318)
ADRBK1 [cilium]
(R-BTA-5632504)
phospho-p-S29-ADRBK1 [plasma membrane]
(R-BTA-111969)
GRK2 [plasma membrane]
(R-BTA-50270)
0.602
4
UniProt:O35158
1
Cdon [plasma membrane]
(R-RNO-197892)
0.524
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.499
2
UniProt:P25098 GRK2
4
GRK2 [plasma membrane]
(R-HSA-50270)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
0.499
2
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