SMURF1/2 dissociates from ub-PTCH1

Stable Identifier
R-HSA-5635865
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

After ubiquitinating PTCH1, the SMURF E3 ligase presumably dissociates, although this has not been studied in detail (Huang et al, 2013; Yue et al, 2014).

Literature References
PubMed ID Title Journal Year
24302888 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

Huang, S, Zhang, Z, Zhang, C, Lv, X, Zheng, X, Chen, Z, Sun, L, Wang, H, Zhu, Y, Zhang, J, Yang, S, Lu, Y, Sun, Q, Tao, Y, Liu, F, Zhao, Y, Chen, D

PLoS Biol. 2013
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, Cheng, SY

Elife 2014
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created