Reactome | SMURF1/2 dissociates from ub-PTCH1

SMURF1/2 dissociates from ub-PTCH1

Stable Identifier

R-HSA-5635865

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

ciliary membrane

ReviewStatus

5/5

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After ubiquitinating PTCH1, the SMURF E3 ligase presumably dissociates, although this has not been studied in detail (Huang et al, 2013; Yue et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24925320	Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception Zhang, YE, Shen, QH, Tang, LY, Chen, Y, Yue, S, Zhang, Z, Tang, Y, Tang, Y, Ding, J, Cheng, SY, Yu, TT	Elife	2014
24302888	Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover Wang, H, Liu, F, Sun, L, Chen, Z, Lv, X, Zhu, Y, Huang, S, Sun, Q, Lu, Y, Tao, Y, Zhang, C, Zhao, Y, Zhang, J, Zhang, Z, Yang, S, Zheng, X, Chen, D	PLoS Biol.	2013