SMURF1/2 dissociates from ub-PTCH1

Stable Identifier
Reaction [dissociation]
Homo sapiens
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After ubiquitinating PTCH1, the SMURF E3 ligase presumably dissociates, although this has not been studied in detail (Huang et al, 2013; Yue et al, 2014).

Literature References
PubMed ID Title Journal Year
24302888 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

Huang, S, Zhang, Z, Zhang, C, Lv, X, Zheng, X, Chen, Z, Sun, L, Wang, H, Zhu, Y, Zhang, J, Yang, S, Lu, Y, Sun, Q, Tao, Y, Liu, F, Zhao, Y, Chen, D

PLoS Biol. 2013
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Yue, S, Tang, LY, Tang, Y, Tang, Y, Shen, QH, Ding, J, Chen, Y, Zhang, Z, Yu, TT, Zhang, YE, Cheng, SY

Elife 2014
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