Reactome | ub-PTCH1 [endocytic vesicle membrane]

ub-PTCH1 [endocytic vesicle membrane]

Stable Identifier

R-HSA-5632520

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

Patched homolog 1, Protein patched homolog 1, PTC1_HUMAN

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External Reference Information

External Reference

UniProt:Q13635 PTCH1

Gene Names

PTCH1, PTCH

Chain

chain:1-1447

Reference Genes

BioGPS Gene:5727 PTCH1

COSMIC (genes):PTCH1 PTCH1

CTD Gene:5727 PTCH1

dbSNP Gene:5727 PTCH1

ENSEMBL:ENSG00000185920 PTCH1

HGNC:9585 PTCH1

KEGG:hsa:5727 PTCH1

Monarch:5727 PTCH1

NCBI Gene:5727 PTCH1

OMIM:601309 PTCH1

UCSC:Q13635 PTCH1

Reference Transcript

Participates

as an output of

PTCH is internalized (Homo sapiens)

Other forms of this molecule

PTCH1 [ciliary membrane]

ub-PTCH1 [ciliary membrane]

PTCH1 [plasma membrane]

Inferred To

Ptch1 [endocytic vesicle membrane] (Mus musculus)

Ptch1 [endocytic vesicle membrane] (Rattus norvegicus)

ptc [endocytic vesicle membrane] (Drosophila melanogaster)

ptc-1 [endocytic vesicle membrane] (Caenorhabditis elegans)

Homologues of ub-PTCH1 [endocytic vesicle membrane] (Caenorhabditis elegans)

PTCH1 [endocytic vesicle membrane] (Bos taurus)

PTCH1 [endocytic vesicle membrane] (Canis familiaris)

PTCH1 [endocytic vesicle membrane] (Sus scrofa)

ptch1 [endocytic vesicle membrane] (Xenopus tropicalis)

ub-PTCH1 [endocytic vesicle membrane] (Gallus gallus)

ptc-3 [endocytic vesicle membrane] (Caenorhabditis elegans)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001077076.1, NP_001077075.1, NP_001077074.1, NP_001077073.1, NP_001077072.1, NP_001077071.1, NP_000255.2

OpenTargets

ENSG00000185920

ENSEMBL

ENSG00000185920, ENSP00000389744, ENSP00000510238, ENST00000711046, ENST00000437951, ENSP00000518556, ENST00000692981, ENSP00000410287, ENST00000430669, ENST00000429896, ENSP00000332353, ENSP00000414823, ENST00000331920

HPA

ENSG00000185920-PTCH1

GeneCards

PTCH1

PRO

Q13635

Pharos - Targets

Q13635

Orphanet

PTCH1

GlyGen

Q13635

PDB

6RMG, 6DMY, 6RTW, 6N7H, 6RTY, 6RTX, 6RVC, 6N7G, 6OEU, 6E1H, 6N7K, 6DMB, 6DMO, 6RVD, 6OEV

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21146	4	phospho-GRK2 [cytosol] (R-BTA-9645318) GRK2 [cilium] (R-BTA-5632504) phospho-GRK2 [plasma membrane] (R-BTA-111969) GRK2 [plasma membrane] (R-BTA-50270)	0.602	4
UniProt:O35158	1	Cdon [plasma membrane] (R-RNO-197892)	0.524	2
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.499	2
UniProt:P25098 GRK2	4	GRK2 [plasma membrane] (R-HSA-50270) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [cytosol] (R-HSA-9645318)	0.499	2

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