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PTCH1 [ciliary membrane]
Stable Identifier
R-HSA-5610415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary membrane
Synonyms
Patched homolog 1, Protein patched homolog 1, PTC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
Activation of SMO (Homo sapiens)
SMO translocates to the cilium (Homo sapiens)
Hh-Npp:BOC:PTCH1 [ciliary membrane] (Homo sapiens)
BOC:PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp:CDON:PTCH [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp:GAS1:PTCH [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Ligand-receptor interactions (Homo sapiens)
Hh-Npp binds BOC:PTCH1 (Homo sapiens)
BOC:PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp:BOC:PTCH1 [ciliary membrane] (Homo sapiens)
BOC:PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp binds CDON and PTCH (Homo sapiens)
Hh-Npp:CDON:PTCH [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp binds GAS1 and PTCH (Homo sapiens)
Hh-Npp:GAS1:PTCH [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
SMURF1/2 bind PTCH1 (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
PTCH1 [ciliary membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13635 PTCH1
Gene Names
PTCH1, PTCH
Chain
chain:1-1447
Reference Genes
COSMIC (genes):PTCH1 PTCH1
dbSNP Gene:5727 PTCH1
ENSEMBL:ENSG00000185920 PTCH1
Participates
as an input of
Hh-Npp binds GAS1 and PTCH (Homo sapiens)
Hh-Npp binds CDON and PTCH (Homo sapiens)
SMURF1/2 bind PTCH1 (Homo sapiens)
as a component of
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
BOC:PTCH1 [ciliary membrane] (Homo sapiens)
Hh-Npp:GAS1:PTCH [ciliary membrane] (Homo sapiens)
Hh-Npp:CDON:PTCH [ciliary membrane] (Homo sapiens)
as an output of
Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling (Homo sapiens)
This entity regulates
Negatively
PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal
(Homo sapiens)
Other forms of this molecule
PTCH1 [plasma membrane]
ub-PTCH1 [endocytic vesicle membrane]
ub-PTCH1 [ciliary membrane]
Inferred To
PTCH1 [ciliary membrane]
(Bos taurus)
PTCH1 [ciliary membrane]
(Canis familiaris)
PTCH1 [ciliary membrane]
(Gallus gallus)
PTCH1 [ciliary membrane]
(Sus scrofa)
Ptch1 [ciliary membrane]
(Mus musculus)
Ptch1 [ciliary membrane]
(Rattus norvegicus)
ptch1 [ciliary membrane]
(Xenopus tropicalis)
ptc [ciliary membrane]
(Drosophila melanogaster)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21146
4
phospho-p-S29-ADRBK1 [cytosol]
(R-BTA-9645318)
ADRBK1 [cilium]
(R-BTA-5632504)
phospho-p-S29-ADRBK1 [plasma membrane]
(R-BTA-111969)
GRK2 [plasma membrane]
(R-BTA-50270)
0.602
4
UniProt:O35158
1
Cdon [plasma membrane]
(R-RNO-197892)
0.524
2
UniProt:P25098 GRK2
4
GRK2 [plasma membrane]
(R-HSA-50270)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
0.499
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.499
2
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