PTCH is internalized

Stable Identifier
Reaction [omitted]
Homo sapiens
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After SMURF-dependent ubiquitination, PTCH1 is internalized to endocytic vesicles for degradation (Rohatgi et al, 2007; Huang et al, 2013; Yue et al, 2014). PTCH1 and SMO show reciprocal changes in localization upon Hh pathway activation, with PTCH moving from the primary cilium to internal vesicles while SMO becomes enriched in the primary cilium after ligand binding (Denef et al, 2000; Rohatgi et al, 2007; Corbit et al, 2005; Kovacs et al, 2008; reviewed in Goetz and Anderson). In mice, internalization of PTCH1 appears to be independent of SMO, while in flies, activated SMO is required to promote the SMURF-dependent downregulation of PTCH (Yue et al, 2014; Huang et al, 2013).
Literature References
PubMed ID Title Journal Year
16136078 Vertebrate Smoothened functions at the primary cilium

Stainier, DY, Singla, V, Norman, AR, Reiter, JF, Aanstad, P, Corbit, KC

Nature 2005
24925320 Requirement of Smurf-mediated endocytosis of Patched1 in Sonic Hedgehog signal reception

Zhang, YE, Shen, QH, Tang, LY, Chen, Y, Yue, S, Zhang, Z, Tang, Y, Tang, Y, Ding, J, Cheng, SY, Yu, TT

Elife 2014
18497258 Beta-arrestin-mediated localization of smoothened to the primary cilium

Chen, W, Liu, R, Kim, J, Wang, J, Chen, M, Whalen, EJ, Kovacs, JJ, Lefkowitz, RJ, Xiao, K

Science 2008
24302888 Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

Wang, H, Liu, F, Sun, L, Chen, Z, Lv, X, Zhu, Y, Huang, S, Sun, Q, Lu, Y, Tao, Y, Zhang, C, Zhao, Y, Zhang, J, Zhang, Z, Yang, S, Zheng, X, Chen, D

PLoS Biol. 2013
10966113 Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

Cohen, SM, Denef, N, Neub├╝ser, D, Perez, L

Cell 2000
17641202 Patched1 regulates hedgehog signaling at the primary cilium

Milenkovic, L, Rohatgi, R, Scott, MP

Science 2007
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