DDIT4 binds 14-3-3 dimer

Stable Identifier
R-HSA-5632738
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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DDIT4 (REDD1) binds 14-3-3 proteins through a conserved 14-3-3 binding motif Arg-X-X-X-Ser/Thr-X-Pro (DeYoung et al. 2008). Binding of DDIT4 to 14-3-3 proteins competes with 14-3-3 binding to TSC2 and thus prevents AKT-mediated inactivation of TSC2 (Cam et al. 2014).

Literature References
PubMed ID Title Journal Year
18198340 Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

DeYoung, MP, Horak, P, Sofer, A, Sgroi, D, Ellisen, LW

Genes Dev. 2008
24366874 p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

Cam, M, Bid, HK, Xiao, L, Zambetti, GP, Houghton, PJ, Cam, H

J. Biol. Chem. 2014
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