Reactome | DDIT4 binds 14-3-3 dimer

DDIT4 binds 14-3-3 dimer

Stable Identifier

R-HSA-5632738

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DDIT4 (REDD1) binds 14-3-3 proteins through a conserved 14-3-3 binding motif Arg-X-X-X-Ser/Thr-X-Pro (DeYoung et al. 2008). Binding of DDIT4 to 14-3-3 proteins competes with 14-3-3 binding to TSC2 and thus prevents AKT-mediated inactivation of TSC2 (Cam et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24366874	p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage Zambetti, GP, Houghton, PJ, Bid, HK, Cam, H, Xiao, L, Cam, M	J. Biol. Chem.	2014
18198340	Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling Horak, P, Sgroi, D, Ellisen, LW, Sofer, A, DeYoung, MP	Genes Dev.	2008