TP63/TP53 stimulates transcription of DDIT4 gene

Stable Identifier
R-HSA-5632386
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP63/TP53 stimulates transcription of DDIT4 gene
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Transcription of DDIT4 (REDD1) gene is stimulated by TP63, both during mouse embryonal development and under conditions of genotoxic and oxidative stress. TP53 stimulates DDIT4 transcription after TP53 activation by ionizing radiation, but it seems that TP63 is the main activator of DDIT4 transcription under stress conditions (Ellisen et al. 2002).
Literature References
PubMed ID Title Journal Year
12453409 REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

Yang, A, Oliner, JD, Minda, K, Ellisen, LW, Haber, DA, McKeon, F, Johannessen, CM, Ramsayer, KD, Beppu, H

Mol. Cell 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
TP63/T53:DDIT4 Gene [nucleoplasm] (Homo sapiens)
Active Unit
TP63 Tetramer/ TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2014-12-23)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Wang, PY  (2014-12-30)
Hwang, PM  (2014-12-30)
Kang, JG  (2014-12-30)
Created
Orlic-Milacic, M  (2014-10-28)
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