RDH5,RDH11 oxidise 11cROL to 11cRAL

Stable Identifier
R-HSA-5362721
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

11-cis-retinol dehydrogenase (RDH5) and RDH11 catalyse the final step in the biosynthesis of 11-cis-retinal (11cRAL), the universal chromophore of visual pigments, whereas RDH8, RDH12, and DHRS3 (retSDR1) catalyze the conversion of all-trans-retinal (atRAL) into all-trans-retinol (atROL) to maintain the cycle (Parker & Crouch 2010). Defects in the RDH5 gene can cause fundus albipunctatus (RPA; MIM:136880), a rare form of stationary night blindness characterised by a delay in the regeneration of cone and rod photopigments (Yamamoto et al. 1999).

Literature References
PubMed ID Title Journal Year
20801113 Retinol dehydrogenases (RDHs) in the visual cycle

Parker, RO, Crouch, RK

Exp. Eye Res. 2010
10369264 Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus

Yamamoto, H, Simon, A, Eriksson, U, Harris, E, Berson, EL, Dryja, TP

Nat. Genet. 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinol dehydrogenase activity of RDH5(24-318), RDH11 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created