Reactome | RDH5,RDH11 oxidise 11cROL to 11cRAL

RDH5,RDH11 oxidise 11cROL to 11cRAL

Stable Identifier

R-HSA-5362721

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

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11-cis-retinol dehydrogenase (RDH5) and RDH11 catalyse the final step in the biosynthesis of 11-cis-retinal (11cRAL), the universal chromophore of visual pigments, whereas RDH8, RDH12, and DHRS3 (retSDR1) catalyze the conversion of all-trans-retinal (atRAL) into all-trans-retinol (atROL) to maintain the cycle (Parker & Crouch 2010). Defects in the RDH5 gene can cause fundus albipunctatus (RPA; MIM:136880), a rare form of stationary night blindness characterised by a delay in the regeneration of cone and rod photopigments (Yamamoto et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
20801113	Retinol dehydrogenases (RDHs) in the visual cycle Parker, RO, Crouch, RK	Exp. Eye Res.	2010
10369264	Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus Yamamoto, H, Simon, A, Eriksson, U, Harris, E, Berson, EL, Dryja, TP	Nat. Genet.	1999