RA biosynthesis pathway

Stable Identifier
R-HSA-5365859
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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RA biosynthesis pathway
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The major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde dehydrogenase (RALDH) gene families (Das et al. 2014, Napoli 2012).
Literature References
PubMed ID Title Journal Year
21621639 Physiological insights into all-trans-retinoic acid biosynthesis

Napoli, JL

Biochim. Biophys. Acta 2012
24393720 Retinoic acid signaling pathways in development and diseases

Karki, R, Torregroza, I, Mahapatra, S, Kambhampati, S, Das, S, Evans, T, Thapa, P, Das, BC, Verma, A, Wallace, DP, Ray, SK, Van Veldhuizen, P, Liu, TC

Bioorg. Med. Chem. 2014
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Orthologous Events
RA biosynthesis pathway (Bos taurus)
RA biosynthesis pathway (Caenorhabditis elegans)
RA biosynthesis pathway (Canis familiaris)
RA biosynthesis pathway (Danio rerio)
RA biosynthesis pathway (Dictyostelium discoideum)
RA biosynthesis pathway (Drosophila melanogaster)
RA biosynthesis pathway (Gallus gallus)
RA biosynthesis pathway (Mus musculus)
RA biosynthesis pathway (Plasmodium falciparum)
RA biosynthesis pathway (Rattus norvegicus)
RA biosynthesis pathway (Saccharomyces cerevisiae)
RA biosynthesis pathway (Schizosaccharomyces pombe)
RA biosynthesis pathway (Sus scrofa)
RA biosynthesis pathway (Xenopus tropicalis)
Authored
Jassal, B  (2014-04-16)
Reviewed
Duester, G  (2014-07-28)
Napoli, JL  (2014-09-01)
Created
Jassal, B  (2014-04-24)
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