Regulation of TNFR1 signaling

Stable Identifier
Homo sapiens
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Tumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). Stimuli and the cellular context dictate cell fate decisions between survival and death which rely on tightly regulated mechanisms with checkpoints on many levels. TNFR1-mediated NFkappaB activation leads to the pro-survival transcriptional program that is both anti-apoptotic and highly proinflammatory. The constitutive NFkappaB or AP1 activation may lead to excessive inflammation which has been associated with a variety of aggressive tumor types (Jackson-Bernitsas DG et al. 2007; Zhang JY et al. 2007). Thus, the tight regulation of TNFalpha:TNFR1 signaling is required to ensure the appropriate cell response to stimuli.

Literature References
PubMed ID Title Journal Year
22435550 Regulation of NF-?B by deubiquitinases

Harhaj, EW, Dixit, VM

Immunol. Rev. 2012
12724336 Regulation of apoptosis: the ubiquitous way

Yu, X, Yang, Y

FASEB J 2003
11432772 Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1

Matsuzawa, A, Ichijo, H

J Biochem 2001
Event Information
Orthologous Events
Cross References
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