GNB2L1 binds IKKA:IKKB:NEMO

Stable Identifier
R-HSA-5626962
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
RACK1 binds IKKA:IKKB:NEMO
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Guanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1) also known as receptor of activated protein kinase C 1 (RACK1) is reported to associate with the IKK complex in a TNF-triggered manner (Yao F et al. 2014). This interaction interfered with TRAF2-mediated recruitment and the subsequent phosphorylation of IKK triggered by TNF. By modulating the interaction between TRAF2 and the IKK complex, GNB2L1 (RACK1) regulated the level of NFkB activation in response to TNF (Yao F et al. 2014).

Literature References
PubMed ID Title Journal Year
24323043 RACK1 modulates NF-?B activation by interfering with the interaction between TRAF2 and the IKK complex

Yao, F, Long, LY, Deng, YZ, Feng, YY, Ying, GY, Bao, WD, Li, G, Guan, DX, Zhu, YQ, Li, JJ, Xie, D

Cell Res. 2014
Participants
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