Reactome | RACK1 binds IKKA:IKKB:NEMO

RACK1 binds IKKA:IKKB:NEMO

Stable Identifier

R-HSA-5626962

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GNB2L1 binds IKKA:IKKB:NEMO

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1) also known as receptor of activated protein kinase C 1 (RACK1) is reported to associate with the IKK complex in a TNF-triggered manner (Yao F et al. 2014). This interaction interfered with TRAF2-mediated recruitment and the subsequent phosphorylation of IKK triggered by TNF. By modulating the interaction between TRAF2 and the IKK complex, GNB2L1 (RACK1) regulated the level of NFkB activation in response to TNF (Yao F et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24323043	RACK1 modulates NF-?B activation by interfering with the interaction between TRAF2 and the IKK complex Yao, F, Long, LY, Deng, YZ, Feng, YY, Ying, GY, Bao, WD, Li, G, Guan, DX, Zhu, YQ, Li, JJ, Xie, D	Cell Res.	2014