Viral inhibitor of caspase-8 activation (UL36) binds caspase-8

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human cytomegalovirus
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Human cytomegalovirus (HCMV) encodes several viral cell death inhibitors that target different key regulators of the extrinsic and intrinsic apoptotic pathways. Viral inhibitor of caspase-8 activation (vICA) protein encoded by the UL36 gene suppresses the extrinsic apoptotic signaling pathway by binding to the prodomain of caspase-8 (CASP8) and preventing its activation (Skaletskaya A et al. 2001; McCormick et al, 2010; Fliss PM & Brune W 2012).

Literature References
PubMed ID Title Journal Year
11427719 A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

Skaletskaya, A, Bartle, LM, Chittenden, T, McCormick, AL, Mocarski, ES, Goldmacher, VS

Proc. Natl. Acad. Sci. U.S.A. 2001
20219915 The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages

McCormick, AL, Roback, L, Livingston-Rosanoff, D, St Clair, C

J. Virol. 2010
Participant Of
Event Information
Name Identifier Synonyms
viral infectious disease 934 Viral disease, virus infection, virus infection
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