Viral inhibitor of caspase-8 activation (UL36) binds caspase-8

Stable Identifier
R-HSA-5692550
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
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Viral inhibitor of caspase-8 activation (UL36) binds caspase-8
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Human cytomegalovirus (HCMV) encodes several viral cell death inhibitors that target different key regulators of the extrinsic and intrinsic apoptotic pathways. Viral inhibitor of caspase-8 activation (vICA) protein encoded by the UL36 gene suppresses the extrinsic apoptotic signaling pathway by binding to the prodomain of caspase-8 (CASP8) and preventing its activation (Skaletskaya A et al. 2001; McCormick et al, 2010; Fliss PM & Brune W 2012).

Literature References
PubMed ID Title Journal Year
20219915 The human cytomegalovirus UL36 gene controls caspase-dependent and -independent cell death programs activated by infection of monocytes differentiating to macrophages

Roback, L, McCormick, AL, St Clair, C, Livingston-Rosanoff, D

J. Virol. 2010
11427719 A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

Goldmacher, VS, Chittenden, T, McCormick, AL, Skaletskaya, A, Mocarski, ES, Bartle, LM

Proc. Natl. Acad. Sci. U.S.A. 2001
Participants
Input
Output
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Event Information
Go Biological Process
suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process (0039650)
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Shamovsky, V  (2015-05-12)
Reviewed
Gillespie, ME  (2015-03-12)
Wajant, H  (2015-08-25)
Created
Shamovsky, V  (2015-05-12)
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