Viral serpin blocks caspase-8 activity

Stable Identifier
R-HSA-2672196
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Vaccinia virus, Cowpox virus
Compartment
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SPI-2/CrmA (cytokine response modifier A) is a poxvirus gene product with homology to members of the serpin (serine protease inhibitor) superfamily. Cowpox virus-derived and vaccinia virus-derived CrmA cDNAs transfected into cells inhibits apoptosis induced by Fas-ligation and activation of TNFR1 (Tewari M and Dixit VM 1995; Miura M et al, 1995; Kettle S et al. 1997). Cowpox virus-derived CrmA was shown to selectively inhibit caspases in Fas-mediated apoptosis, showing the highest affinity for interleukin-1 beta-converting enzyme (ICE) and a similarly high affinity for caspase-8, Ki = 0.95 nM (Zhou Q et al. 1997).

Literature References
PubMed ID Title Journal Year
9049422 Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever

Kettle, S, Alcamí, A, Khanna, A, Ehret, R, Jassoy, C, Smith, GL

J. Gen. Virol. 1997
9065443 Target protease specificity of the viral serpin CrmA. Analysis of five caspases

Zhou, Q, Snipas, S, Orth, K, Muzio, M, Dixit, VM, Salvesen, GS

J. Biol. Chem. 1997
7667287 Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

Miura, M, Friedlander, RM, Yuan, J

Proc. Natl. Acad. Sci. U.S.A. 1995
7531702 Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

Tewari, M, Dixit, VM

J. Biol. Chem. 1995
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