LUBAC comlex binds OTULIN

Stable Identifier
R-HSA-5661517
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor kappaB (NFkappaB) signaling. Deubiquitinases are key regulators of Ub signaling. OTULIN (also known as FAM105B) is an OTU domain deubiquitinase with high activity and unique specificity for Met1-linked polyUb (Keusekotten K et al. 2013; Rivkin E et al. 2013). OTULIN antagonizes processes involving LUBAC, including tumor necrosis factor alpha (TNFalpha), poly(I:C), NOD2 and Wnt signaling (Fiil BK et al. 2013; Keusekotten K et al. 2013; Rivkin E et al. 2013). OTULIN interacts directly with the N-terminal PUB domain of HOIP, a component of the LUBAC complex, via a conserved PUB-interacting motif (PIM) in OTULIN (Elliott PR et al. 2014; Schaeffer V et al. 2014). Furthermore, OTULIN phosphorylation within PIM was found to prevent the LUBAC:OTULIN complex formation (Elliott PR et al. 2014).

Literature References
PubMed ID Title Journal Year
23746843 OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

Keusekotten, K, Elliott, PR, Glockner, L, Fiil, BK, Damgaard, RB, Kulathu, Y, Wauer, T, Hospenthal, MK, Gyrd-Hansen, M, Krappmann, D, Hofmann, K, Komander, D

Cell 2013
24726327 Binding of OTULIN to the PUB domain of HOIP controls NF-?B signaling

Schaeffer, V, Akutsu, M, Olma, MH, Gomes, LC, Kawasaki, M, Dikic, I

Mol. Cell 2014
24726323 Molecular basis and regulation of OTULIN-LUBAC interaction

Elliott, PR, Nielsen, SV, Marco-Casanova, P, Fiil, BK, Keusekotten, K, Mailand, N, Freund, SM, Gyrd-Hansen, M, Komander, D

Mol. Cell 2014
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