K63polyUb-RIPK1 is deubiquitinated

Stable Identifier
Reaction [omitted]
Homo sapiens
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K63-deubiquitination of RIP1 abolishes its ability to activate NF-kappa-B upon TNF-alpha stimulation and leads to the formation of the cytosolic caspase-8 containing complex II and subsequent apoptosis.
Literature References
PubMed ID Title Journal Year
34876703 The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling

Liu, M, Wu, B, Ge, Y, Wei, YG, Lu, Z, Li, H, Zhang, Y, Zhou, X, Lei, Z, Liu, CH, Cui, CP, Qiang, L, Zheng, H, Zhao, M, Peng, Z, Wang, J, Dai, H, Fu, Y, Zhang, L

Cell Mol Immunol 2022
23313255 Ubiquitin-specific protease 4 promotes TNF-?-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma

Pan, X, Zhao, W, Zhang, L, Hou, X, Wang, L

FEBS Lett. 2013
22435550 Regulation of NF-?B by deubiquitinases

Harhaj, EW, Dixit, VM

Immunol. Rev. 2012
22848449 NEMO inhibits programmed necrosis in an NF?B-independent manner by restraining RIP1

Hase, H, O'Donnell, MA, Legarda, D, Ting, AT

PLoS ONE 2012
24098568 CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis

McQuade, T, Chan, FK, Moquin, DM

PLoS ONE 2013
35941131 OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

Sawasaki, T, Komakura, K, Hosomi, S, Takahashi, H, Tsuruta, D, Shiota, M, Tokunaga, F, Shimizu, K, Oikawa, D, Kosako, H, Wanibuchi, H, Gi, M

Cell Death Dis 2022
22179575 De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

AbuAli, G, Mahul-Mellier, AL, Pazarentzos, E, Grimm, S, Datler, C, Lin, B, Iwasawa, R

Cell Death Differ. 2012
19910467 Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1

Cao, G, Xu, G, Gu, X, Wang, H, Shi, Y, Tan, X, Sun, W, Zhang, T, Yang, J, Qin, J, Burlingame, S

J. Biol. Chem. 2010
18178551 NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

Evans, PC, Rawlinson, L, Chaudhury, H, Enesa, K, Zakkar, M, Luong, le A, Dean, JL, Haskard, DO, Mason, JC

J. Biol. Chem. 2008
Catalyst Activity

Lys63-specific deubiquitinase activity of RIPK1 deubiquitinases [cytosol]

This event is regulated
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Orthologous Events
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