K63-deubiquitination of RIP1 abolishes its ability to activate NFkB upon TNF-alpha stimulation and leads to the formation of the cytosolic caspase-8 containing complex II and subsequent apoptosis.
Pan, X, Zhao, W, Zhang, L, Hou, X, Wang, L
Harhaj, EW, Dixit, VM
Hase, H, O'Donnell, MA, Legarda, D, Ting, AT
McQuade, T, Chan, FK, Moquin, DM
AbuAli, G, Mahul-Mellier, AL, Pazarentzos, E, Grimm, S, Datler, C, Lin, B, Iwasawa, R
Cao, G, Xu, G, Gu, X, Wang, H, Shi, Y, Tan, X, Sun, W, Zhang, T, Yang, J, Qin, J, Burlingame, S
Evans, PC, Rawlinson, L, Chaudhury, H, Enesa, K, Zakkar, M, Luong, le A, Dean, JL, Haskard, DO, Mason, JC
Lys63-specific deubiquitinase activity of RIPK1 deubiquitinases [cytosol]
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