RIPK1 is deubiquitinated

Stable Identifier
Reaction [omitted]
Homo sapiens
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K63-deubiquitination of RIP1 abolishes its ability to activate NFkB upon TNF-alpha stimulation and leads to the formation of the cytosolic caspase-8 containing complex II and subsequent apoptosis.

Literature References
PubMed ID Title Journal Year
22435550 Regulation of NF-?B by deubiquitinases

Harhaj, EW, Dixit, VM

Immunol. Rev. 2012
23313255 Ubiquitin-specific protease 4 promotes TNF-?-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma

Hou, X, Wang, L, Zhang, L, Pan, X, Zhao, W

FEBS Lett. 2013
22848449 NEMO inhibits programmed necrosis in an NF?B-independent manner by restraining RIP1

O'Donnell, MA, Hase, H, Legarda, D, Ting, AT

PLoS ONE 2012
24098568 CYLD deubiquitinates RIP1 in the TNF?-induced necrosome to facilitate kinase activation and programmed necrosis

Moquin, DM, McQuade, T, Chan, FK

PLoS ONE 2013
22179575 De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

Mahul-Mellier, AL, Pazarentzos, E, Datler, C, Iwasawa, R, AbuAli, G, Lin, B, Grimm, S

Cell Death Differ. 2012
19910467 Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1

Xu, G, Tan, X, Wang, H, Sun, W, Shi, Y, Burlingame, S, Gu, X, Cao, G, Zhang, T, Qin, J, Yang, J

J. Biol. Chem. 2010
18178551 NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

Enesa, K, Zakkar, M, Chaudhury, H, Luong, le A, Rawlinson, L, Mason, JC, Haskard, DO, Dean, JL, Evans, PC

J. Biol. Chem. 2008
Participant Of
Catalyst Activity
Catalyst Activity
Lys63-specific deubiquitinase activity of RIPK1 deubiquitinases [cytosol]
Physical Entity
This event is regulated
Negatively by
Positively by
Orthologous Events
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