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MAP2K3-3(1-26) [cytosol]
Stable Identifier
R-HSA-5211399
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MAP2K3-3 small LF fragment, MAP2k3b(1-26), Dual specificity mitogen-activated protein kinase kinase 3MAP2K3b(1-26)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of anthrax toxins (Homo sapiens)
Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)
MAP2K3-3(1-26) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11104681
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
Mock, M
,
Napolitani, G
,
Montecucco, C
,
Bernardi, L
,
Vitale, G
Biochem. J.
2000
External Reference Information
External Reference
UniProt:P46734-3 MAP2K3
Gene Names
MAP2K3, MEK3, MKK3, PRKMK3, SKK2
Other Identifiers
11742801_a_at
1622_at
16832268
2075_s_at
207667_PM_s_at
207667_s_at
215498_PM_s_at
215498_s_at
215499_PM_at
215499_at
3714730
3714731
3714733
3714745
3714748
3714749
3714751
3714752
3714753
3714754
3714755
3714758
3714759
3714764
3714766
3714767
3714768
3714769
3714770
3714772
5606
8005707
A_14_P109219
A_23_P118427
A_24_P296698
D87116_at
GE594548
GE62082
GO:0000165
GO:0000166
GO:0001817
GO:0001934
GO:0002931
GO:0003012
GO:0003013
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0007165
GO:0007507
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0023052
GO:0031098
GO:0035331
GO:0035924
GO:0036211
GO:0038066
GO:0043226
GO:0043410
GO:0043536
GO:0045860
GO:0045893
GO:0048856
GO:0048870
GO:0051770
GO:0060048
GO:0071222
GO:0072709
GO:0090398
GO:0106310
GO:0140096
HMNXSV003017442
HMNXSV003039726
Hs.180533.2.S1_3p_a_at
Hs.180533.2.S1_3p_x_at
ILMN_1680777
ILMN_1790534
PH_hs_0010680
TC17000297.hg
TC17002123.hg
g4506098_3p_a_at
Participates
as an output of
Anthrax lef cleaves target cell MAP2K3 (MEK3) (Homo sapiens)
Other forms of this molecule
MAP2K3-3(27-347) [cytosol]
MAP2K3-3 [cytosol]
Disease
Name
Identifier
Synonyms
anthrax disease
DOID:7427
Cross References
RefSeq
XP_016880347.1
,
NP_001303261.1
,
XP_005256780.1
,
NP_659731.1
,
NP_002747.2
,
XP_011522261.1
,
XP_016880348.1
ZINC - World Drugs
MP2K3_HUMAN
Guide to Pharmacology - Targets
2064
OpenTargets
ENSG00000034152
ZINC - FDA approved
MP2K3_HUMAN
ZINC - Substances
MP2K3_HUMAN
ZINC - Biogenic
MP2K3_HUMAN
ZINC target
P46734
PRO
P46734
ZINC - Investigational
MP2K3_HUMAN
IntEnz
2.7.12.2
HPA
ENSG00000034152-MAP2K3
GeneCards
P46734
Ensembl
ENSP00000345083
,
ENSG00000034152
,
ENST00000316920
,
ENSP00000319139
,
ENST00000342679
,
ENSP00000355081
,
ENST00000361818
Pharos - Targets
P46734
ZINC - Predictions - Purchasable
MP2K3_HUMAN
HMDB Protein
HMDBP02743
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.757
6
UniProt:Q16539 MAPK14
7
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.744
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.589
5
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.483
2
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