Anthrax lef cleaves target cell MAP2K3 (MEK3)

Stable Identifier
R-HSA-5211400
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
ReviewStatus
5/5
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Anthrax lef cleaves target cell MAP2K3 (MEK3)
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lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K3 (MEK3, mitogen activated protein kinase kinase 3), isoform 3 (Pellizzari et al. 1999).
Literature References
PubMed ID Title Journal Year
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Leppla, SH, Arora, N

Mol. Microbiol. 1994
10580119 Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha

Mock, M, Pellizzari, R, Montecucco, C, Guidi-Rontani, C, Vitale, G

FEBS Lett. 1999
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Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-11)
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