Anthrax lef cleaves target cell MAP2K3 (MEK3)

Stable Identifier
R-HSA-5211400
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
ReviewStatus
5/5
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Anthrax lef cleaves target cell MAP2K3 (MEK3)
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lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K3 (MEK3, mitogen activated protein kinase kinase 3), isoform 3 (Pellizzari et al. 1999).
Literature References
PubMed ID Title Journal Year
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Arora, N, Leppla, SH

Mol. Microbiol. 1994
10580119 Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS/IFNgamma-induced release of NO and TNFalpha

Pellizzari, R, Guidi-Rontani, C, Vitale, G, Mock, M, Montecucco, C

FEBS Lett. 1999
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Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Mondo
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-11)
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