Reactome | IL8 [extracellular region]

IL8 [extracellular region]

Stable Identifier

R-HSA-447095

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-8, IL8_HUMAN, CXCL8

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External Reference Information

External Reference

UniProt:P10145 CXCL8

Gene Names

CXCL8, IL8

Chain

signal peptide:1-20, chain:21-99, chain:23-99, chain:27-99, chain:28-99, chain:29-99, chain:30-99, chain:31-99

Reference Genes

BioGPS Gene:3576 CXCL8

COSMIC (genes):CXCL8 CXCL8

CTD Gene:3576 CXCL8

dbSNP Gene:3576 CXCL8

ENSEMBL:ENSG00000169429 IL8

HGNC:6025 CXCL8

KEGG:hsa:3576 CXCL8

Monarch:3576 CXCL8

NCBI Gene:3576 CXCL8

OMIM:146930 CXCL8

UCSC:P10145 CXCL8

Reference Transcript

RefSeq:NM_000584.3 CXCL8

Other Identifiers

11718841_s_at

11754026_a_at

11763226_x_at

1369_s_at

16967771

202859_PM_x_at

202859_x_at

211506_PM_s_at

211506_s_at

2731333

2731334

2731335

2731336

2731337

2731338

2731339

2731340

2731341

35372_r_at

3576

8095680

A_14_P105298

A_14_P107514

A_32_P87013

A_33_P3243230

GE62180

GO:0001525

GO:0002237

GO:0002376

GO:0005125

GO:0005153

GO:0005515

GO:0005576

GO:0005615

GO:0006935

GO:0006952

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0008009

GO:0008201

GO:0008285

GO:0010628

GO:0010629

GO:0016192

GO:0019722

GO:0030155

GO:0030593

GO:0031328

GO:0031623

GO:0034976

GO:0035556

GO:0042119

GO:0044344

GO:0045091

GO:0045236

GO:0045744

GO:0045766

GO:0048018

GO:0048566

GO:0048856

GO:0048870

GO:0050930

GO:0060326

GO:0060354

GO:0061844

GO:0070098

GO:0071222

GO:0071347

GO:0071356

GO:0090023

GO:0098542

GO:0098772

GO:2000535

HMNXSV003043499

HMNXSV003047985

ILMN_1666733

ILMN_2184373

M28130_rna1_s_at

PH_hs_0000069

TC04000408.hg

TC04002067.hg

Y00787_s_at

g10834977_3p_at

g10834977_3p_x_at

g12641914_3p_a_at

Participates

as a member of

as an output of

as a component of

DARC:IL8 [plasma membrane] (Homo sapiens)

as an input of

DARC is a non-specific receptor for many chemokines (Homo sapiens)

Inferred To

k60 [extracellular region] (Gallus gallus)

CXCL8 [extracellular region] (Bos taurus)

CXCL8 [extracellular region] (Canis familiaris)

CXCL8 [extracellular region] (Gallus gallus)

CXCL8 [extracellular region] (Sus scrofa)

Homologues of IL8 [extracellular region] (Canis familiaris)

Homologues of IL8 [extracellular region] (Gallus gallus)

IL8 [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_000575.1

ZINC - World Drugs

IL8_HUMAN

OpenTargets

ENSG00000169429

ENSEMBL

ENSP00000306512

ZINC - FDA approved

IL8_HUMAN

ZINC - Substances

IL8_HUMAN

ZINC target

P10145

PRO

P10145

PDB

1IKL, 6LFO, 8IC0, 1IKM, 1ILP, 1ILQ, 1ICW, 6LFM, 6WZM, 6N2U, 5D14, 5WDZ, 4XDX, 1QE6, 1ROD, 1IL8, 2IL8, 6XMN, 3IL8

HPA

ENSG00000169429-CXCL8

Pharos - Targets

P10145

ZINC - Predictions - Purchasable

IL8_HUMAN

HMDB Protein

HMDBP02377

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25025 CXCR2	2	CXCR2 [plasma membrane] (R-HSA-373796) CXCR2 [secretory granule membrane] (R-HSA-6804771)	0.609	3
ChEBI:28304 HEPARIN			0.609	5
UniProt:P9WGV3 SAHH			0.602	3
UniProt:Q6MX51 Q6MX51			0.602	3
UniProt:P9WMN3 GLMU			0.602	3
UniProt:P98066 TNFAIP6	3	TNFAIP6 [ficolin-1-rich granule lumen] (R-HSA-6803311) TNFAIP6 [extracellular region] (R-HSA-6803348) TNFAIP6 [tertiary granule lumen] (R-HSA-6803341)	0.558	15
UniProt:P02776 PF4	4	PF4(32-101) [extracellular region] (R-HSA-61823) PF4(32-101) [platelet alpha granule lumen] (R-HSA-114652) PF4(48-101) [platelet alpha granule lumen] (R-HSA-114628) PF4(48-101) [extracellular region] (R-HSA-114629)	0.558	2