Reactome | PF4(32-101) [platelet alpha granule lumen]

PF4(32-101) [platelet alpha granule lumen]

Stable Identifier

R-HSA-114652

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

PF4, Platelet factor 4, PF-4, CXCL4, Oncostatin A, Iroplact

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02776 PF4

Gene Names

PF4, CXCL4, SCYB4

Chain

signal peptide:1-31, chain:32-101, chain:48-101

Reference Genes

BioGPS Gene:5196 PF4

COSMIC (genes):PF4 PF4

CTD Gene:5196 PF4

dbSNP Gene:5196 PF4

ENSEMBL:ENSG00000163737 PF4

HGNC:8861 PF4

KEGG:hsa:5196 PF4

Monarch:5196 PF4

NCBI Gene:5196 PF4

OMIM:173460 PF4

UCSC:P02776 PF4

Reference Transcript

RefSeq:NM_002619.4 PF4

Participates

as a member of

Other forms of this molecule

PF4(32-101) [extracellular region]

PF4(48-101) [platelet alpha granule lumen]

PF4(48-101) [extracellular region]

Inferred To

Pf4 [platelet alpha granule lumen] (Mus musculus)

Pf4 [platelet alpha granule lumen] (Rattus norvegicus)

CXCL8 [platelet alpha granule lumen] (Gallus gallus)

Homologues of PF4(32-101) [platelet alpha granule lumen] (Gallus gallus)

PF4(32-101) [platelet alpha granule lumen] (Bos taurus)

CXCL13 [platelet alpha granule lumen] (Gallus gallus)

CXCL13L3 [platelet alpha granule lumen] (Gallus gallus)

IL8L1 [platelet alpha granule lumen] (Gallus gallus)

cxcl8a [platelet alpha granule lumen] (Danio rerio)

Cross References

RefSeq

NP_002610.1

ENSEMBL

ENST00000296029, ENSG00000163737, ENSP00000296029

OpenTargets

ENSG00000163737

GeneCards

PF4

HPA

ENSG00000163737-PF4

ZINC - Substances

PLF4_HUMAN

ZINC target

P02776

PRO

P02776

Pharos - Targets

P02776

PDB

1RHP, 1DN3, 1F9S, 4R9Y, 1F9R, 1F9Q, 1PFM, 1PFN, 4RAU, 4R9W

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78556 CCL20	1	CCL20(27-96) [extracellular region] (R-HSA-373097)	0.558	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	6
UniProt:P10145 CXCL8	1	IL8 [extracellular region] (R-HSA-447095)	0.558	2
UniProt:Q99616 CCL13	1	CCL13 [extracellular region] (R-HSA-8862740)	0.558	2
UniProt:O15444 CCL25	1	CCL25 [extracellular region] (R-HSA-373096)	0.558	3
UniProt:P13500 CCL2	1	CCL2 [extracellular region] (R-HSA-443967)	0.558	2
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	4

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