Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PF4(32-101) [platelet alpha granule lumen]
Stable Identifier
R-HSA-114652
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet alpha granule lumen
Synonyms
PF4, Platelet factor 4, PF-4, CXCL4, Oncostatin A, Iroplact
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
PF4 gene transcription is stimulated by RUNX1:CBFB (Homo sapiens)
PF4 [platelet alpha granule lumen] (Homo sapiens)
PF4(32-101) [platelet alpha granule lumen] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
PF4(32-101) [platelet alpha granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P02776 PF4
Gene Names
PF4, CXCL4, SCYB4
Chain
signal peptide:1-31, chain:32-101, chain:48-101
Reference Genes
COSMIC (genes):PF4 PF4
dbSNP Gene:5196 PF4
ENSEMBL:ENSG00000163737 PF4
Participates
as a member of
Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)
PF4 [platelet alpha granule lumen] (Homo sapiens)
Other forms of this molecule
PF4(32-101) [extracellular region]
PF4(48-101) [platelet alpha granule lumen]
PF4(48-101) [extracellular region]
Inferred To
cxcl8b.3 [platelet alpha granule lumen]
(Danio rerio)
Homologues of PF4(32-101) [platelet alpha granule lumen]
(Danio rerio)
PF4(32-101) [platelet alpha granule lumen]
(Bos taurus)
PF4(32-101) [platelet alpha granule lumen]
(Mus musculus)
PF4(32-101) [platelet alpha granule lumen]
(Rattus norvegicus)
cxcl8b.1 [platelet alpha granule lumen]
(Danio rerio)
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13501 CCL5
1
CCL5(24-91) [extracellular region]
(R-HSA-373108)
0.558
6
UniProt:O15444 CCL25
1
CCL25 [extracellular region]
(R-HSA-373096)
0.558
3
UniProt:P48061 CXCL12
1
CXCL12(22-93) [extracellular region]
(R-HSA-2980693)
0.558
4
UniProt:P13500 CCL2
1
CCL2 [extracellular region]
(R-HSA-443967)
0.558
2
UniProt:P10145 CXCL8
1
IL8 [extracellular region]
(R-HSA-447095)
0.558
2
UniProt:P78556 CCL20
1
CCL20(27-96) [extracellular region]
(R-HSA-373097)
0.558
2
UniProt:Q99616 CCL13
1
CCL13 [extracellular region]
(R-HSA-8862740)
0.558
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text