Reactome | CXCL8 [extracellular region]

CXCL8 [extracellular region]

Stable Identifier

R-CFA-447095

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

IL8, A0A8I3RT67

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        Chemokine receptors bind chemokines (Canis familiaris)
        
        Receptor CXCR1 binds CXCL6 and CXCL8 ligands (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR1:CXCR1 ligands [plasma membrane] (Canis familiaris)
        
        CXCR1 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Canis familiaris)
        
        CXCR2 ligands [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        DARC is a non-specific receptor for many chemokines (Canis familiaris)
        
        DARC:IL8 [plasma membrane] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)
        
        Homologues of IL8 [extracellular region] (Canis familiaris)
        
        CXCL8 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RT67

Gene Names

CXCL8

Reference Genes

ENSEMBL:ENSCAFG00845006275.1

UCSC:A0A8I3RT67 CXCL8

Other Identifiers

403850

Cfa.3510.1.S1_s_at

Cfa.3510.1.S2_at

Cfa.3510.2.S1_s_at

GO:0002237

GO:0002376

GO:0005153

GO:0005576

GO:0006935

GO:0006952

GO:0006955

GO:0008009

GO:0008201

GO:0010628

GO:0010629

GO:0016192

GO:0030155

GO:0030593

GO:0031623

GO:0034976

GO:0035556

GO:0042119

GO:0044344

GO:0045091

GO:0045744

GO:0045766

GO:0048018

GO:0048566

GO:0048856

GO:0048870

GO:0050930

GO:0060354

GO:0071222

GO:0071347

GO:0071356

GO:0098772

GO:2000535

Participates

as a member of

Homologues of IL8 [extracellular region] (Canis familiaris)

Inferred From

IL8 [extracellular region] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFG00845006275, ENSCAFT00845011119, ENSCAFP00845008676

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