Reactome | PF4(48-101) [extracellular region]

PF4(48-101) [extracellular region]

Stable Identifier

R-HSA-114629

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Low-affinity platelet factor IV

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)
        
        CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)
        
        CXCR2 ligands [extracellular region] (Homo sapiens)
        
        CXCL4 homotetramer [extracellular region] (Homo sapiens)
        
        PF4(48-101) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02776 PF4

Gene Names

PF4, CXCL4, SCYB4

Chain

signal peptide:1-31, chain:32-101, chain:48-101

Reference Genes

BioGPS Gene:5196 PF4

COSMIC (genes):PF4 PF4

CTD Gene:5196 PF4

dbSNP Gene:5196 PF4

ENSEMBL:ENSG00000163737 PF4

HGNC:8861 PF4

KEGG:hsa:5196 PF4

Monarch:5196 PF4

NCBI Gene:5196 PF4

OMIM:173460 PF4

UCSC:P02776 PF4

Reference Transcript

RefSeq:NM_002619.3 PF4

Participates

as a member of

Platelet alpha granule contents [extracellular region] (Homo sapiens)

as a component of

CXCL4 homotetramer [extracellular region] (Homo sapiens)

Other forms of this molecule

PF4(32-101) [extracellular region]

PF4(32-101) [platelet alpha granule lumen]

PF4(48-101) [platelet alpha granule lumen]

Inferred To

Homologues of PF4(48-101) [extracellular region] (Danio rerio)

cxcl8b.1 [extracellular region] (Danio rerio)

cxcl8b.3 [extracellular region] (Danio rerio)

PF4(48-101) [extracellular region] (Bos taurus)

PF4(48-101) [extracellular region] (Mus musculus)

PF4(48-101) [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_002610.1

ENSEMBL

ENSG00000163737, ENST00000296029, ENSP00000296029

OpenTargets

ENSG00000163737

GeneCards

PF4

HPA

ENSG00000163737-PF4

ZINC - Substances

PLF4_HUMAN

ZINC target

P02776

PRO

P02776

Pharos - Targets

P02776

PDB

1PFN, 1PFM, 4R9W, 4R9Y, 1F9R, 1F9S, 1F9Q, 1DN3, 1RHP, 4RAU

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15444 CCL25	1	CCL25 [extracellular region] (R-HSA-373096)	0.558	3
UniProt:P48061 CXCL12	1	CXCL12(22-93) [extracellular region] (R-HSA-2980693)	0.558	4
UniProt:P13500 CCL2	1	CCL2 [extracellular region] (R-HSA-443967)	0.558	2
UniProt:P78556 CCL20	1	CCL20(27-96) [extracellular region] (R-HSA-373097)	0.558	2
UniProt:Q99616 CCL13	1	CCL13 [extracellular region] (R-HSA-8862740)	0.558	2
UniProt:P10145 CXCL8	1	IL8 [extracellular region] (R-HSA-447095)	0.558	2
UniProt:P13501 CCL5	1	CCL5(24-91) [extracellular region] (R-HSA-373108)	0.558	6