DARC is a non-specific receptor for many chemokines

Stable Identifier
R-HSA-374251
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The Duffy blood group system consists of two antigens defining four phenotypes (Marsh WL, 1975). Duffy antigen/receptor for chemokines (DARC) (Chaudhuri A et al, 1993) carries the Duffy (Fy) blood group and acts as a widely expressed promiscuous chemokine receptor. The chemokine interleukin-8 is one example shown here.

Literature References
PubMed ID Title Journal Year
12956774 Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites

Tournamille, C, Filipe, A, Wasniowska, K, Gane, P, Lisowska, E, Cartron, JP, Colin, Y, Le Van Kim, C

Br J Haematol 2003
8248172 Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite

Chaudhuri, A, Polyakova, J, Zbrzezna, V, Williams, K, Gulati, S, Pogo, AO

Proc Natl Acad Sci U S A 1993
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