Reactome | DARC is a non-specific receptor for many chemokines

DARC is a non-specific receptor for many chemokines

Stable Identifier

R-HSA-374251

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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DARC is a non-specific receptor for many chemokines

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The Duffy blood group system consists of two antigens defining four phenotypes (Marsh WL, 1975). Duffy antigen/receptor for chemokines (DARC) (Chaudhuri A et al, 1993) carries the Duffy (Fy) blood group and acts as a widely expressed promiscuous chemokine receptor. The chemokine interleukin-8 is one example shown here.

Literature References

PubMed ID	Title	Journal	Year
8248172	Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite Chaudhuri, A, Polyakova, J, Zbrzezna, V, Williams, K, Gulati, S, Pogo, AO	Proc Natl Acad Sci U S A	1993
12956774	Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites Tournamille, C, Filipe, A, Wasniowska, K, Gane, P, Lisowska, E, Cartron, JP, Colin, Y, Le Van Kim, C	Br J Haematol	2003