DARC is a non-specific receptor for many chemokines

Stable Identifier
Reaction [binding]
Homo sapiens
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The Duffy blood group system consists of two antigens defining four phenotypes (Marsh WL, 1975). Duffy antigen/receptor for chemokines (DARC) (Chaudhuri A et al, 1993) carries the Duffy (Fy) blood group and acts as a widely expressed promiscuous chemokine receptor. The chemokine interleukin-8 is one example shown here.

Literature References
PubMed ID Title Journal Year
8248172 Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite

Polyakova, J, Pogo, AO, Gulati, S, Chaudhuri, A, Zbrzezna, V, Williams, K

Proc Natl Acad Sci U S A 1993
12956774 Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites

Filipe, A, Tournamille, C, Lisowska, E, Cartron, JP, Gane, P, Le Van Kim, C, Colin, Y, Wasniowska, K

Br J Haematol 2003
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